Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833650 | 0.89 | MAPT (0.41) | NPC1RAB9AHPGDALDH1A1MAPT | |
| SCHEMBL9833569 | 0.79 | TUBB4A (0.35) | HPGDALDH1A1MAPTCYP1A2CYP3A4 | |
| SCHEMBL9833086 | 0.79 | NPC1 (0.38) | NPC1RAB9AESR1HPGDALDH1A1 | |
| SCHEMBL9831796 | 0.76 | NPC1 (0.35) | NPC1RAB9AESR1HPGDALDH1A1 | |
| SCHEMBL9799824 | 0.73 | NPC1 (0.35) | NPC1ESR1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9831386 | 0.68 | MAPT (0.45) | NPC1RAB9AESR1HPGDALDH1A1 | |
| SCHEMBL9799815 | 0.68 | L3MBTL1 (0.35) | NPC1RAB9AMAPT | |
| SCHEMBL9834177 | 0.65 | MAPT (0.42) | RAB9AHPGDALDH1A1MAPTCYP1A2 | |
| SCHEMBL28677160 | 0.65 | NPC1 (0.47) | NPC1RAB9AHPGDCYP3A4CYP2C9 | |
| SCHEMBL9799796 | 0.64 | ALDH1A1 (0.40) | ALDH1A1MAPTCYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297782-B1 | A THIOPHENE DERIVATIVE AND PROCESS FOR PREPARING THE SAME | TANABE SEIYAKU CO., LTD. (JP) | 1991-05-22 | — | — | EP | disclosed |
| EP-0258289-A4 | PEPTIDE ANALOGS | — | 1991-01-02 | — | — | EP | disclosed |
| US-4857543-A | TREATMENT OF GASTROINTESTINAL DISORDERS | TANABE SEIYAKU CO., LTD. (JP) | 1989-08-15 | — | — | US | disclosed |
| EP-0297782-A1 | A thiophene derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1989-01-04 | — | — | EP | disclosed |
| EP-0258289-A1 | PEPTIDE ANALOGS | ABBOTT LABORATORIES (US) | 1988-03-09 | — | — | EP | disclosed |
| WO-1987004349-A1 | PEPTIDE ANALOGS | DELLARIA JOSEPH | 1987-07-30 | — | — | WO | disclosed |