Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 5/20 | 0.32 |
| ▸ | MAPT | P10636 | 5/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834177 | 0.89 | MAPT (0.42) | RAB9AHPGDMAPTALDH1A1CYP1A2 | |
| SCHEMBL9833086 | 0.80 | NPC1 (0.38) | NPC1RAB9AESR1HPGDMAPT | |
| SCHEMBL9833083 | 0.79 | OPRM1 (0.40) | HPGDMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9832269 | 0.78 | MAPT (0.36) | ESR1HPGDMAPTALDH1A1CYP3A4 | |
| SCHEMBL9832379 | 0.76 | NPC1 (0.35) | NPC1RAB9AESR1HPGDMAPT | |
| SCHEMBL9830678 | 0.71 | RIPK1 (0.38) | ESR1KMT2A | |
| SCHEMBL9799280 | 0.69 | SIGMAR1 (0.40) | NPC1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9831386 | 0.68 | MAPT (0.45) | NPC1RAB9AESR1HPGDMAPT | |
| SCHEMBL9799293 | 0.67 | FDPS (0.38) | NPC1RAB9AMAPTLMNAL3MBTL1 | |
| SCHEMBL16268640 | 0.66 | MAOA (0.35) | ESR1HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297782-B1 | A THIOPHENE DERIVATIVE AND PROCESS FOR PREPARING THE SAME | TANABE SEIYAKU CO., LTD. (JP) | 1991-05-22 | — | — | EP | disclosed |
| US-4857543-A | TREATMENT OF GASTROINTESTINAL DISORDERS | TANABE SEIYAKU CO., LTD. (JP) | 1989-08-15 | — | — | US | disclosed |
| EP-0297782-A1 | A thiophene derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1989-01-04 | — | — | EP | disclosed |