Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 8/20 | 0.47 |
| ▸ | REN | P00797 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9832598 | 0.84 | BACE1 (0.45) | BACE1RENPSEN1PSEN2APH1B | |
| SCHEMBL13996047 | 0.79 | LMNA (0.58) | ALDH1A1LMNA | |
| SCHEMBL14011507 | 0.79 | LMNA (0.58) | ALDH1A1LMNA | |
| SCHEMBL13929428 | 0.79 | LMNA (0.58) | ALDH1A1LMNA | |
| SCHEMBL9831068 | 0.78 | BACE1 (0.49) | BACE1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9833327 | 0.78 | ALDH1A1 (0.54) | RENALDH1A1LMNA | |
| SCHEMBL10188332 | 0.77 | CTSK (0.51) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9697661 | 0.77 | CTSS (0.54) | BACE1RENPSEN1PSEN2APH1B | |
| SCHEMBL7429081 | 0.74 | REN (0.49) | BACE1RENPSEN1PSEN2APH1B | |
| SCHEMBL7441770 | 0.74 | PSEN1 (0.49) | BACE1RENPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0258289-A4 | PEPTIDE ANALOGS | — | 1991-01-02 | — | — | EP | disclosed |
| US-4857507-A | HYPOTENSIVE AGENT | ABBOTT LABORATORIES (US) | 1989-08-15 | — | — | US | disclosed |
| EP-0258289-A1 | PEPTIDE ANALOGS | ABBOTT LABORATORIES (US) | 1988-03-09 | — | — | EP | disclosed |
| WO-1987004349-A1 | PEPTIDE ANALOGS | DELLARIA JOSEPH | 1987-07-30 | — | — | WO | disclosed |