Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9830077 | 0.93 | TSHR (0.43) | ALDH1A1PPARGTSHRLMNAHPGD | |
| SCHEMBL9833231 | 0.90 | PPARG (0.46) | ALDH1A1PPARGTSHRLMNAHPGD | |
| SCHEMBL2502826 | 0.84 | TSHR (0.44) | ALDH1A1PPARGTSHRLMNAHPGD | |
| SCHEMBL9831726 | 0.83 | KEAP1 (0.44) | ALDH1A1PPARGTSHRLMNAHPGD | |
| SCHEMBL9831443 | 0.82 | PPARG (0.50) | ALDH1A1PPARGLMNAKDM4EMEN1 | |
| SCHEMBL9832835 | 0.81 | ALDH1A1 (0.47) | ALDH1A1TSHRLMNAHPGDKDM4E | |
| SCHEMBL9832767 | 0.80 | PPARG (0.62) | ALDH1A1PPARGTSHRLMNAHPGD | |
| SCHEMBL9832189 | 0.78 | ALDH1A1 (0.49) | ALDH1A1TSHRLMNAKDM4EMEN1 | |
| SCHEMBL9830898 | 0.78 | ALDH1A1 (0.55) | ALDH1A1PPARGHPGDKDM4EGAA | |
| SCHEMBL9831770 | 0.78 | PPARG (0.50) | ALDH1A1PPARGTSHRLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |