Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.39 |
| ▸ | KCNJ6 | P48051 | 7/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 7/20 | 0.37 |
| ▸ | KCNJ5 | P48544 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 3/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831040 | 0.94 | RIPK1 (0.41) | RIPK1KCNJ6KCNJ3KCNJ5MEN1 | |
| SCHEMBL9832532 | 0.94 | ALDH1A1 (0.42) | RIPK1KCNJ6KCNJ3KCNJ5MEN1 | |
| SCHEMBL9833948 | 0.93 | ALDH1A1 (0.40) | RIPK1MEN1POLBKMT2AALDH1A1 | |
| SCHEMBL9316496 | 0.93 | MEN1 (0.40) | RIPK1KCNJ6KCNJ3KCNJ5MEN1 | |
| SCHEMBL9832144 | 0.92 | RIPK1 (0.41) | RIPK1KCNJ6KCNJ3KCNJ5ALDH1A1 | |
| SCHEMBL9833865 | 0.92 | POLB (0.39) | RIPK1KCNJ6KCNJ3KCNJ5MEN1 | |
| SCHEMBL9832608 | 0.91 | NPC1 (0.40) | RIPK1KCNJ6KCNJ3KCNJ5MEN1 | |
| SCHEMBL9316263 | 0.88 | RIPK1 (0.41) | RIPK1KCNJ6KCNJ3KCNJ5MEN1 | |
| SCHEMBL10571543 | 0.88 | RIPK1 (0.42) | RIPK1KCNJ6KCNJ3KCNJ5MEN1 | |
| SCHEMBL9523052 | 0.88 | RIPK1 (0.37) | RIPK1KCNJ6KCNJ3KCNJ5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0274443-A1 | Heteroaryl 3-oxo-propanenitrile derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-07-13 | — | — | EP | claimed |
| EP-0274443-B1 | HETEROARYL 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-05-29 | — | — | EP | disclosed |
| US-4816467-A | BACTERICIDES, VIRICIDES | FARMITALIA CARLO ERBA S.R.L (IT) | 1989-03-28 | — | — | US | disclosed |
| EP-0274443-A1 | Heteroaryl 3-oxo-propanenitrile derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-07-13 | — | — | EP | disclosed |