SCHEMBL983350

SCHEMBL983350

CC1(C)OB(c2ccc3c(cnn3C3CCCCO3)c2)OC1(C)C

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXRA P19793 1/20 0.51
RXRB P28702 1/20 0.51
RXRG P48443 1/20 0.51
IRAK4 Q9NWZ3 1/20 0.40
CYP4F2 P78329 5/20 0.38
CYP4A11 Q02928 5/20 0.38
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.38
POLB P06746 1/20 0.38
HIF1A Q16665 1/20 0.34
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
ATR Q13535 3/20 0.32
DGAT1 O75907 1/20 0.32
TNKS O95271 2/20 0.32
USP30 Q70CQ3 1/20 0.32
LPL P06858 1/20 0.32
LIPG Q9Y5X9 1/20 0.32
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29390069 1.00 RXRA (0.51) RXRARXRBRXRGIRAK4CYP4F2
SCHEMBL2144475 0.91 IRAK4 (0.47) RXRARXRBRXRGIRAK4CYP4F2
SCHEMBL29741019 0.91 IRAK4 (0.47) RXRARXRBRXRGIRAK4CYP4F2
SCHEMBL17678315 0.82 IRAK4 (0.44) IRAK4HIF1ATNKSLPLLIPG
SCHEMBL30242559 0.82 CYP4F2 (0.38) RXRARXRBRXRGIRAK4CYP4F2
SCHEMBL12370610 0.82 CYP4F2 (0.38) RXRARXRBRXRGIRAK4CYP4F2
SCHEMBL17678304 0.82 IRAK4 (0.46) IRAK4TNKSLPLLIPG
SCHEMBL24153533 0.81 RXRA (0.43) RXRARXRBRXRGIRAK4CYP4F2
SCHEMBL20424091 0.81 RXRA (0.43) RXRARXRBRXRGIRAK4CYP4F2
SCHEMBL18480146 0.81 CYP4F2 (0.39) RXRARXRBRXRGIRAK4CYP4F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014147-A1 STAT6 DEGRADERS GILEAD SCIENCES INC (US) 2026-01-15 US disclosed
US-20250340551-A1 SMALL MOLECULE MODULATORS OF STAT6 GILEAD SCIENCES INC (US) 2025-11-06 US disclosed
US-20250325677-A1 STAT6 DEGRADERS GILEAD SCIENCES INC (US) 2025-10-23 US disclosed
WO-2024040768-A1 5-PYRIDINE-1H-INDAZOLE COMPOUND, PHARMACEUTICAL COMPOSITION, AND USE 中国药科大学 2024-02-29 WO disclosed
US-20230219956-A1 QUINAZOLINE COMPOUND AND PHARMACEUTICAL APPLICATION THEREOF BETTA PHARMACEUTICALS CO.,LTD (CN) 2023-07-13 US disclosed
WO-2023122600-A1 PIPERAZINE INDAZOLE GLUCOCORTICOID RECEPTOR ANTAGONISTS CORCEPT THERAPEUTICS INCORPORATED (US) 2023-06-29 WO disclosed
US-20220281821-A1 INDAZOLE COMPOUNDS AND THEIR PHARMACEUTICAL COMPOSITIONS JINAN UNIVERSITY (CN) 2022-09-08 US disclosed
CN-114072387-A Indazole compound and medicinal composition and application thereof 暨南大学 2022-02-18 CN disclosed
EP-3746079-A1 ANTIBODY DRUG CONJUGATES (ADCS) WITH NAMPT INHIBITORS Bayer Aktiengesellschaft (DE) 2020-12-09 EP disclosed
CN-112040951-A Antibody Drug Conjugates (ADC) with NAMPT inhibitors 拜耳股份公司 2020-12-04 CN disclosed
US-20130203702-A1 HETEROCYCLYL-PYRIDINYL-BASED BIPHOSPHONIC ACID, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, COMPOSITION THEREOF AND METHOD OF USE THEREOF THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2013-08-08 US disclosed
US-20130203702-A1 HETEROCYCLYL-PYRIDINYL-BASED BIPHOSPHONIC ACID, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, COMPOSITION THEREOF AND METHOD OF USE THEREOF THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2013-08-08 US disclosed
EP-2257545-B1 PYRROLIDINYL DERIVATIVES AND USES THEREOF HOFFMANN LA ROCHE (CH) 2011-08-31 EP disclosed
EP-2257545-B1 PYRROLIDINYL DERIVATIVES AND USES THEREOF HOFFMANN LA ROCHE (CH) 2011-08-31 EP disclosed
US-20110021556-A1 PYRROLIDINYL DERIVATIVES AND USES THEREOF HOFFMAN-LA ROCHE, INC. (US) 2011-01-27 US disclosed
US-20110021556-A1 PYRROLIDINYL DERIVATIVES AND USES THEREOF HOFFMAN-LA ROCHE, INC. (US) 2011-01-27 US disclosed
US-20110021556-A1 PYRROLIDINYL DERIVATIVES AND USES THEREOF HOFFMAN-LA ROCHE, INC. (US) 2011-01-27 US disclosed
EP-2257545-A1 PYRROLIDINYL DERIVATIVES AND USES THEREOF F. Hoffmann-La Roche AG (CH) 2010-12-08 EP disclosed
WO-2009115427-A1 PYRROLIDINYL DERIVATIVES AND USES THEREOF F. HOFFMANN-LA ROCHE AG (CH) 2009-09-24 WO disclosed
WO-2009115427-A1 PYRROLIDINYL DERIVATIVES AND USES THEREOF F. HOFFMANN-LA ROCHE AG (CH) 2009-09-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130203702-A1 HETEROCYCLYL-PYRIDINYL-BASED BIPHOSPHONIC ACID, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, COMPOSITION THEREOF AND METHOD OF USE THEREOF FDPS, GGPS1, PPA1 RXRA 1547/4885RXRB 1357/4885RXRG 1639/4885
US-20110021556-A1 PYRROLIDINYL DERIVATIVES AND USES THEREOF SLC6A3, MAOB, TPH2 RXRA 3262/4885RXRB 3254/4885RXRG 3166/4885
US-20250325677-A1 STAT6 DEGRADERS STAT6, STAT5B, STAT1 RXRA 129/4885RXRB 115/4885RXRG 96/4885
US-20250340551-A1 SMALL MOLECULE MODULATORS OF STAT6 STAT6, STAT1, STAT5B RXRA 81/4885RXRB 61/4885RXRG 48/4885
US-20230219956-A1 QUINAZOLINE COMPOUND AND PHARMACEUTICAL APPLICATION THEREOF H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, ABCG2, NQO2 RXRA 4148/4885RXRB 4049/4885RXRG 4083/4885
US-20260014147-A1 STAT6 DEGRADERS STAT6, NCOR1, CBR1 RXRA 76/4885RXRB 83/4885RXRG 113/4885
US-20220281821-A1 INDAZOLE COMPOUNDS AND THEIR PHARMACEUTICAL COMPOSITIONS TNK2, TNNI3K, CSNK1G3 RXRA 2973/4885RXRB 2130/4885RXRG 2417/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.