Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835639 | 0.93 | ALDH1A1 (0.42) | ALDH1A1ALOX15LTA4HMAOBBCHE | |
| SCHEMBL11010577 | 0.89 | POLB (0.38) | ALOX15LTA4HS1PR1TBXAS1KMT2A | |
| SCHEMBL9836629 | 0.88 | CYP2C19 (0.41) | ALDH1A1TBXAS1MEN1KMT2AADRA1D | |
| SCHEMBL11014211 | 0.88 | KDM4E (0.38) | S1PR1TBXAS1MEN1KMT2A | |
| SCHEMBL9834568 | 0.85 | HSP90AA1 (0.38) | ALOX15TBXAS1ADRA1DADRA1AADRA1B | |
| SCHEMBL11012750 | 0.83 | KIT (0.36) | ALDH1A1ALOX15MEN1KMT2AHSP90AA1 | |
| SCHEMBL9836562 | 0.79 | P2RX7 (0.36) | ALDH1A1ALOX15MEN1KMT2A | |
| SCHEMBL11016894 | 0.78 | CYP2D6 (0.37) | TBXAS1KMT2A | |
| SCHEMBL11016261 | 0.77 | MAPT (0.35) | ALDH1A1S1PR1MEN1KMT2ABCHE | |
| SCHEMBL9835161 | 0.77 | HRH3 (0.38) | ALOX15LTA4HDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129879-B1 | A [1] benzepino(3,4-b)pyridine derivative | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-09-11 | — | — | EP | claimed |
| US-4547496-A | Antiulcer [1] benzepino[3,4-b]pyridine and compositions | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1985-10-15 | — | — | US | claimed |
| EP-0129879-A2 | A [1] benzepino(3,4-b)pyridine derivative | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1985-01-02 | — | — | EP | claimed |
| JP-60089419-A | — | — | None | — | — | JP | disclosed |
| EP-0129879-B1 | A [1] benzepino(3,4-b)pyridine derivative | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-09-11 | — | — | EP | disclosed |
| US-4547496-A | Antiulcer [1] benzepino[3,4-b]pyridine and compositions | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1985-10-15 | — | — | US | disclosed |
| JP-S6089419-A | ANTIULCER AGENT COMPRISING NOVEL (1)BENZEPINO (3,4-B)PYRIDINE DERIVATIVE AS ACTIVE INGREDIENT | KYOWA HAKKO KOGYO CO LTD | 1985-05-20 | — | — | JP | disclosed |
| EP-0129879-A2 | A [1] benzepino(3,4-b)pyridine derivative | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1985-01-02 | — | — | EP | disclosed |