SCHEMBL9834568

SCHEMBL9834568

CC(C)N(CCNC1c2ccccc2OCc2ncccc21)C(C)C

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.38
HSP90AB1 P08238 1/20 0.38
HRH1 P35367 2/20 0.32
CHRM2 P08172 1/20 0.32
CHRM4 P08173 1/20 0.32
CHRM5 P08912 1/20 0.32
CHRM1 P11229 1/20 0.32
CHRM3 P20309 1/20 0.32
TBXAS1 P24557 1/20 0.32
MAPK14 Q16539 1/20 0.32
SIGMAR1 Q99720 1/20 0.32
ADRA1D P25100 1/20 0.32
ADRA1A P35348 1/20 0.32
ADRA1B P35368 1/20 0.32
CHRNB2 P17787 1/20 0.31
CHRNA4 P43681 1/20 0.31
HTR1A P08908 1/20 0.31
HTR1D P28221 1/20 0.31
SLC22A2 O15244 1/20 0.30
SLC22A1 O15245 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9836629 0.87 CYP2C19 (0.41) HRH1CHRM2CHRM4CHRM5CHRM1
SCHEMBL9834971 0.85 ALDH1A1 (0.36) HSP90AA1HSP90AB1TBXAS1ADRA1DADRA1A
SCHEMBL9835639 0.81 ALDH1A1 (0.42) HSP90AA1HSP90AB1ALOX15
SCHEMBL9835913 0.80 P2RX7 (0.36) TBXAS1MAPK14
SCHEMBL11016894 0.77 CYP2D6 (0.37) HRH1TBXAS1SIGMAR1HTR1AHTR2C
SCHEMBL9835161 0.76 HRH3 (0.38) KCNH2ALOX15TSHR
SCHEMBL9835877 0.76 GRIN1 (0.42) CYP3A4
SCHEMBL11010577 0.75 POLB (0.38) HSP90AA1HSP90AB1TBXAS1SIGMAR1HTR1A
SCHEMBL9836609 0.75 MEN1 (0.41) CYP3A4
SCHEMBL11014211 0.74 KDM4E (0.38) TBXAS1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0129879-B1 A [1] benzepino(3,4-b)pyridine derivative KYOWA HAKKO KOGYO CO., LTD. (JP) 1991-09-11 EP claimed
US-4547496-A Antiulcer [1] benzepino[3,4-b]pyridine and compositions KYOWA HAKKO KOGYO CO., LTD. (JP) 1985-10-15 US claimed
EP-0129879-A2 A [1] benzepino(3,4-b)pyridine derivative KYOWA HAKKO KOGYO CO., LTD. (JP) 1985-01-02 EP claimed
EP-0129879-B1 A [1] benzepino(3,4-b)pyridine derivative KYOWA HAKKO KOGYO CO., LTD. (JP) 1991-09-11 EP disclosed
US-4547496-A Antiulcer [1] benzepino[3,4-b]pyridine and compositions KYOWA HAKKO KOGYO CO., LTD. (JP) 1985-10-15 US disclosed
EP-0129879-A2 A [1] benzepino(3,4-b)pyridine derivative KYOWA HAKKO KOGYO CO., LTD. (JP) 1985-01-02 EP disclosed