Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7784816 | 0.80 | SIGMAR1 (0.62) | LMNAMEN1KMT2AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10646143 | 0.77 | TDP1 (0.39) | MEN1KMT2AMAPTSMN1; SMN2HTR1A | |
| SCHEMBL8777053 | 0.72 | ALDH1A1 (0.67) | LMNAMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL4217666 | 0.72 | RAB9A (0.43) | MEN1KMT2AMAPTSMN1; SMN2HTR1A | |
| SCHEMBL8801774 | 0.71 | NR1H2 (0.62) | LMNAMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL9369850 | 0.69 | ALDH1A1 (0.47) | MEN1KMT2AMAPTSMN1; SMN2HTR1A | |
| SCHEMBL10853404 | 0.69 | MEN1 (0.47) | LMNAMEN1KMT2ASMN1; SMN2HTR1A | |
| SCHEMBL17260678 | 0.68 | TDP1 (0.68) | MEN1KMT2AALDH1A1HSD17B10RAB9A | |
| SCHEMBL9369038 | 0.68 | ALDH1A1 (0.46) | MEN1KMT2AMAPTSMN1; SMN2HTR1A | |
| SCHEMBL10050510 | 0.68 | RAB9A (0.85) | MEN1KMT2AMAPTSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161218-B1 | BENZO-(PYRANO AND THIOPYRANO)PYRIDINES | CIBA-GEIGY AG (CH) | 1991-06-26 | — | — | EP | disclosed |
| US-4721787-A | CONDENSATION, REDUCTION, DEHYDRATION | CIBA-GEIGY CORPORATION (US) | 1988-01-26 | — | — | US | disclosed |
| US-4604397-A | Certain benzo-(pyrano and thiopyrano)-pyridines, useful as CNS agents | CIBA-GEIGY CORPORATION (US) | 1986-08-05 | — | — | US | disclosed |
| EP-0161218-A2 | Benzo-(pyrano and thiopyrano)pyridines | CIBA-GEIGY AG (CH) | 1985-11-13 | — | — | EP | disclosed |