SCHEMBL7784816

SCHEMBL7784816

COc1ccc2c(c1)C(CCCN1C(=O)c3ccccc3C1=O)=CCC2

nearest known ligand 0.62

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 4/20 0.62
ABCB1 P08183 1/20 0.57
MEN1 O00255 2/20 0.52
LMNA P02545 2/20 0.52
KMT2A Q03164 2/20 0.52
MAPT P10636 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
HSD17B10 Q99714 1/20 0.50
ALDH1A1 P00352 1/20 0.50
HPGD P15428 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
RXFP1 Q9HBX9 1/20 0.50
HTR1A P08908 4/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9835348 0.80 LMNA (0.50) MEN1LMNAKMT2AMAPTSMN1; SMN2
SCHEMBL9166662 0.77 SIGMAR1 (1.00) SIGMAR1ABCB1
SCHEMBL7779874 0.76 SIGMAR1 (0.58) SIGMAR1ABCB1
SCHEMBL9249093 0.76 SIGMAR1 (0.58) SIGMAR1ABCB1
SCHEMBL7784806 0.76 SIGMAR1 (0.58) SIGMAR1ABCB1
SCHEMBL7779938 0.75 SIGMAR1 (0.57) SIGMAR1ABCB1
SCHEMBL9284248 0.75 SIGMAR1 (1.00) SIGMAR1ABCB1HTR1A
SCHEMBL10609000 0.75 RAB9A (0.50) KMT2AMAPTSMN1; SMN2HPGDNPSR1
SCHEMBL9281388 0.75 SIGMAR1 (1.00) SIGMAR1ABCB1
SCHEMBL8777053 0.73 ALDH1A1 (0.67) MEN1LMNAKMT2AMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0848699-B1 BENZOCYCLOALKENE COMPOUNDS WITH MELATONINE RECEPTOR BINDING AFFINITY, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2001-10-24 EP disclosed
US-6235789-B1 GLANDULAR DISORDERS; SLEEP DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-05-22 US disclosed
EP-0848699-A1 BENZOCYCLOALKENE COMPOUNDS WITH MELATONINE RECEPTOR BINDING AFFINITY, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1998-06-24 EP disclosed
EP-0781271-A1 BENZOCYCLOALKENE COMPOUNDS, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1997-07-02 EP disclosed
WO-1997005098-A1 BENZOCYCLOALKENE COMPOUNDS WITH MELATONINE RECEPTOR BINDING AFFINITY, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-02-13 WO disclosed
WO-1996008466-A1 BENZOCYCLOALKENE COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-03-21 WO disclosed