SCHEMBL9835655

SCHEMBL9835655

COc1cc(N(Cl)C(=O)Cl)ccc1F

nearest known ligand 0.43

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
GRM4 Q14833 2/20 0.41
LMNA P02545 1/20 0.39
MAPK1 P28482 1/20 0.39
HTT P42858 1/20 0.39
RAB9A P51151 1/20 0.39
BACE1 P56817 2/20 0.39
TAS2R14 Q9NYV8 1/20 0.37
TAS1R3 Q7RTX0 1/20 0.36
TAS1R1 Q7RTX1 1/20 0.36
TAS1R2 Q8TE23 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9836314 0.85 GRM4 (0.42) GRM4LMNAMAPK1HTTRAB9A
SCHEMBL9835415 0.82 ALDH1A1 (0.42) GRM4LMNA
SCHEMBL9836772 0.73 MTNR1A (0.49)
SCHEMBL23904325 0.73 NQO2 (0.44) LMNAMAPK1
SCHEMBL22973 0.73 RAB9A (0.51) GRM4LMNAMAPK1HTTRAB9A
SCHEMBL16969131 0.72 MEN1 (0.46) GRM4LMNAMAPK1HTTRAB9A
SCHEMBL9836984 0.71 GRM4 (0.42) GRM4LMNARAB9ATAS1R3TAS1R1
SCHEMBL9834275 0.69 CES2 (0.41) RAB9A
SCHEMBL9837683 0.69 RORC (0.41) LMNAHTTRAB9A
SCHEMBL9835945 0.69 KCNQ3 (0.38) LMNABACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0241559-B1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-10-30 EP disclosed
US-4983751-A Chemical intermediates SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-01-08 US disclosed
US-4818272-A NONPHYTOTOXICITY FOR CROPS HELICAL STREAMS SAGAMI CHEMICAL RESEARCH CENTER (JP) 1989-04-04 US disclosed
EP-0241559-A1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1987-10-21 EP disclosed