Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835833 | 0.84 | LMNA (0.40) | LMNAKDM4EL3MBTL1HPGDMAPT | |
| SCHEMBL8801436 | 0.82 | PTGS2 (0.36) | KMT2AMEN1GSK3BNR1H2NR1H3 | |
| SCHEMBL6388610 | 0.77 | MEN1 (0.40) | L3MBTL1HPGDMAPTKMT2AMEN1 | |
| SCHEMBL19304186 | 0.74 | PTGS2 (0.37) | L3MBTL1KMT2AMEN1GSK3BPTGS2 | |
| SCHEMBL21419681 | 0.74 | GSK3B (0.36) | KMT2AMEN1GSK3BPTGS2 | |
| SCHEMBL6693898 | 0.74 | PTGS2 (0.45) | GSK3BNR1H2NR1H3PTGS2 | |
| SCHEMBL12810280 | 0.74 | PTGS1 (0.45) | KDM4EL3MBTL1HPGDMAPTKMT2A | |
| SCHEMBL22718487 | 0.73 | NPC1 (0.36) | KDM4EHPGDMAPTKMT2AMEN1 | |
| SCHEMBL13524782 | 0.73 | KMT2A (0.41) | KDM4EHPGDMAPTKMT2AMEN1 | |
| SCHEMBL13883926 | 0.73 | PTGS2 (0.44) | GSK3BNR1H2NR1H3PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0133156-B1 | 1,4-DIKETOPYRROLO-(3,4-C) PYRROLES | CIBA-GEIGY AG (CH) | 1991-07-10 | — | — | EP | disclosed |
| US-4666455-A | Compositions pigmented with N-substituted 1,4-diketopyrrolo-[3,4-c]-pyrroles | CIBA-GEIGY CORPORATION (US) | 1987-05-19 | — | — | US | disclosed |
| US-4585878-A | N-substituted 1,4-diketopyrrolo-[3,4-c]-pyrroles | CIBA-GEIGY CORPORATION (US) | 1986-04-29 | — | — | US | disclosed |
| EP-0133156-A2 | 1,4-Diketopyrrolo-(3,4-c) pyrroles | CIBA-GEIGY AG (CH) | 1985-02-13 | — | — | EP | disclosed |