Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836013 | 0.84 | LMNA (0.39) | LMNACA12CA9NR1H2NR1H3 | |
| SCHEMBL7489174 | 0.76 | NR1H2 (0.40) | LMNACA12CA9NR1H2NR1H3 | |
| SCHEMBL9835835 | 0.76 | NR1H2 (0.56) | LMNANR1H2NR1H3KMT2AKDM4E | |
| SCHEMBL5073360 | 0.74 | NR1H2 (0.57) | NR1H2NR1H3KMT2AMEN1NPSR1 | |
| SCHEMBL10757746 | 0.71 | CASP3 (0.53) | LMNACA12CA9NR1H2NR1H3 | |
| SCHEMBL7500087 | 0.71 | LMNA (0.43) | LMNANR1H2NR1H3KDM4EPOLB | |
| SCHEMBL1357288 | 0.71 | CA12 (0.51) | CA12CA9 | |
| SCHEMBL29842458 | 0.71 | CA12 (0.51) | CA12CA9 | |
| SCHEMBL7496165 | 0.70 | KDM4E (0.53) | LMNANR1H2NR1H3KDM4EMAPT | |
| SCHEMBL9836829 | 0.70 | NPC1 (0.49) | CA12CA9NR1H2NR1H3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0133156-B1 | 1,4-DIKETOPYRROLO-(3,4-C) PYRROLES | CIBA-GEIGY AG (CH) | 1991-07-10 | — | — | EP | disclosed |
| US-4666455-A | Compositions pigmented with N-substituted 1,4-diketopyrrolo-[3,4-c]-pyrroles | CIBA-GEIGY CORPORATION (US) | 1987-05-19 | — | — | US | disclosed |
| US-4585878-A | N-substituted 1,4-diketopyrrolo-[3,4-c]-pyrroles | CIBA-GEIGY CORPORATION (US) | 1986-04-29 | — | — | US | disclosed |
| EP-0133156-A2 | 1,4-Diketopyrrolo-(3,4-c) pyrroles | CIBA-GEIGY AG (CH) | 1985-02-13 | — | — | EP | disclosed |