Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 12/20 | 0.47 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.45 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.45 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 5/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46315 | 0.79 | CYP11B2 (0.50) | CYP11B2BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL21831983 | 0.78 | CYP11B2 (0.49) | CYP11B2BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL2051397 | 0.78 | BMPR1B (0.50) | CYP11B2BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL31178367 | 0.78 | CYP11B2 (0.49) | CYP11B2BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL30404193 | 0.78 | BMPR1B (0.50) | CYP11B2BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL25317019 | 0.78 | CYP11B2 (0.49) | CYP11B2BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL25921027 | 0.78 | CYP11B2 (0.49) | CYP11B2BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL7323714 | 0.73 | GABRA5 (0.41) | CYP11B2CYP11B1 | |
| SCHEMBL7412272 | 0.72 | CYP11B2 (0.32) | CYP11B2 | |
| SCHEMBL7404024 | 0.71 | CYP11B2 (0.44) | CYP11B2BMPR1BBMPR1AACVRL1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0438446-A1 | PYRIDAZINONE-, PYRAZOLONE- AND PYRIDONE-NAPHTHERIDINONE COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING SAME, AND THEIR USES | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-07-31 | — | — | EP | disclosed |
| WO-1990003790-A1 | PYRIDAZINONE-, PYRAZOLONE- AND PYRIDONE-NAPHTHERIDINONE COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING SAME, AND THEIR USES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1990-04-19 | — | — | WO | disclosed |
| US-4906629-A | Pyridazinone and pyrazolone compounds, cardiotonic compositions including same, and their uses | RORER PHARMACEUTICAL CORPORATION (US) | 1990-03-06 | — | — | US | disclosed |