Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR34 | Q9UPC5 | 9/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9838462 | 0.92 | GPR132 (0.48) | GPR34 | |
| SCHEMBL9836354 | 0.87 | GPR34 (0.48) | GPR34MEN1KMT2APKMSMN1; SMN2 | |
| SCHEMBL9837251 | 0.86 | POLB (0.46) | GPR34MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9837508 | 0.83 | KMT2A (0.56) | MEN1ALDH1A1KMT2A | |
| SCHEMBL9836985 | 0.78 | ALOX15 (0.42) | MEN1ALDH1A1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL7296506 | 0.77 | GPR34 (0.73) | GPR34MEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL10727176 | 0.77 | GPR34 (0.73) | GPR34MEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL7970010 | 0.77 | GPR34 (0.73) | GPR34MEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL10724456 | 0.74 | GPR34 (0.83) | GPR34MEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL28965739 | 0.74 | GPR34 (0.69) | GPR34MEN1ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0238357-B1 | 1,2,4-TRIAZINONE DERIVATIVES, THEIR PREPARATION AND USE | Sankyo Company Limited (JP) | 1991-05-29 | — | — | EP | disclosed |
| US-4898862-A | 1,2,4-triazinone derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1990-02-06 | — | — | US | disclosed |
| EP-0238357-A2 | 1,2,4-Triazinone derivatives, their preparation and use | Sankyo Company Limited (JP) | 1987-09-23 | — | — | EP | disclosed |