Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834011 | 0.84 | KDM4E (0.48) | ALOX15MAPTLMNANPY1RNPY2R | |
| SCHEMBL9837508 | 0.81 | KMT2A (0.56) | MEN1KMT2AALDH1A1ADORA2AADORA2B | |
| SCHEMBL7330323 | 0.80 | MAPT (0.65) | ALOX15KMT2AMAPTLMNANPY1R | |
| SCHEMBL9836752 | 0.78 | GPR34 (0.56) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL10804020 | 0.77 | GPR119 (0.46) | GPR119ALDH1A1SMN1; SMN2KDM4EPDE2A | |
| SCHEMBL9835637 | 0.76 | KDM4E (0.59) | KMT2AALDH1A1SMN1; SMN2KDM4EPDE3B | |
| SCHEMBL10459751 | 0.75 | ACHE (0.51) | KMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL9834714 | 0.75 | ACHE (0.48) | KMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL9835352 | 0.75 | GPR119 (0.46) | MEN1KMT2AMAPTLMNAGPR119 | |
| Water SCHEMBL9836678 | 0.74 | ACHE (0.48) | KMT2AALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0238357-B1 | 1,2,4-TRIAZINONE DERIVATIVES, THEIR PREPARATION AND USE | Sankyo Company Limited (JP) | 1991-05-29 | — | — | EP | disclosed |
| US-4898862-A | 1,2,4-triazinone derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1990-02-06 | — | — | US | disclosed |
| EP-0238357-A2 | 1,2,4-Triazinone derivatives, their preparation and use | Sankyo Company Limited (JP) | 1987-09-23 | — | — | EP | disclosed |