Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563484 | 0.94 | MMP8 (0.46) | MMP8L3MBTL1MAPK1TSHRTDP1 | |
| SCHEMBL20254521 | 0.89 | MMP8 (0.43) | MMP8L3MBTL1MAPK1TSHRTDP1 | |
| SCHEMBL12185043 | 0.86 | LOXL2 (0.45) | MMP8L3MBTL1MAPK1TSHRTDP1 | |
| SCHEMBL9632008 | 0.86 | ALDH1A1 (0.51) | MMP8L3MBTL1MAPK1TSHRTDP1 | |
| SCHEMBL8802162 | 0.86 | ALDH1A1 (0.47) | L3MBTL1MAPK1TSHRCYP4F2CYP4A11 | |
| SCHEMBL12191878 | 0.84 | L3MBTL1 (0.43) | MMP8L3MBTL1MAPK1TSHRTDP1 | |
| SCHEMBL12191879 | 0.84 | L3MBTL1 (0.43) | MMP8L3MBTL1MAPK1TSHRTDP1 | |
| SCHEMBL2496064 | 0.84 | L3MBTL1 (0.43) | MMP8L3MBTL1MAPK1TSHRTDP1 | |
| SCHEMBL22098310 | 0.83 | PPARG (0.47) | MMP8MAPK1TSHRCYP4F2CYP4A11 | |
| SCHEMBL27744395 | 0.83 | SMN1; SMN2 (0.43) | MMP8L3MBTL1MAPK1TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0219308-B1 | 2-SUBSTITUTED QUINOLINES | MERCK FROSST CANADA INC. (CA) | 1991-10-23 | — | — | EP | disclosed |
| EP-0219308-A2 | 2-Substituted quinolines | MERCK FROSST CANADA INC. (CA) | 1987-04-22 | — | — | EP | disclosed |