Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563484 | 0.92 | MMP8 (0.46) | ALDH1A1TP53KMT2AL3MBTL1MEN1 | |
| SCHEMBL20254521 | 0.87 | MMP8 (0.43) | ALDH1A1TP53L3MBTL1MMP8LMNA | |
| SCHEMBL12191879 | 0.86 | L3MBTL1 (0.43) | ALDH1A1TP53L3MBTL1MMP8LMNA | |
| SCHEMBL9837282 | 0.86 | MMP8 (0.42) | ALDH1A1TP53SMN1; SMN2L3MBTL1MMP8 | |
| SCHEMBL12191878 | 0.86 | L3MBTL1 (0.43) | ALDH1A1TP53L3MBTL1MMP8LMNA | |
| SCHEMBL2496064 | 0.86 | L3MBTL1 (0.43) | ALDH1A1TP53L3MBTL1MMP8LMNA | |
| SCHEMBL17604992 | 0.85 | ALDH1A1 (0.63) | ALDH1A1TP53KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL12185043 | 0.84 | LOXL2 (0.45) | ALDH1A1TP53SMN1; SMN2L3MBTL1MMP8 | |
| SCHEMBL27744395 | 0.84 | SMN1; SMN2 (0.43) | ALDH1A1TP53KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL15851320 | 0.83 | SLC7A5 (0.45) | ALDH1A1TP53KMT2AHPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2600874-B1 | PYRIMIDINE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | AMGEN INC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-8716281-B2 | Pyrimidine compounds that inhibit anaplastic lymphoma kinase | AMGEN INC. (US) | 2014-05-06 | — | — | US | disclosed |
| US-20130158019-A1 | PYRIMIDINE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | AMGEN INC. (US) | 2013-06-20 | — | — | US | disclosed |
| EP-0343182-B1 | ALCOHOLS WITH 3-METHYL OR 3,5-DIMETHYL GROUPS, THEIR PRODUCTION AND THEIR USE AS AROMATICS | Consortium für elektrochemische Industrie GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |
| US-4968668-A | Alcohols having 3-methyl or 3,5-dimethyl or 3,5-dimethylphenyl groups, a process for their preparation and a fragrance composition containing same | CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) | 1990-11-06 | — | — | US | disclosed |
| EP-0343182-A1 | ALCOHOLS WITH 3-METHYL OR 3,5-DIMETHYL GROUPS, THEIR PRODUCTION AND THEIR USE AS AROMATICS. | CONSORTIUM ELEKTROCHEM IND (DE) | 1989-11-29 | — | — | EP | disclosed |
| WO-1988005770-A1 | ALCOHOLS WITH 3-METHYL OR 3,5-DIMETHYL GROUPS THEIR PRODUCTION AND THEIR USE AS AROMATICS | Consortium für elektrochemische Industrie GmbH (DE) | 1988-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158019-A1 | PYRIMIDINE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | DCK, DTYMK, TYMS | ALDH1A1 725/4885TP53 344/4885KMT2A 1393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.