Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | LDLR | P01130 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837839 | 0.98 | NFE2L2 (0.47) | NFE2L2KIF11LDLRNPC1ALDH1A1 | |
| SCHEMBL9837596 | 0.74 | NFE2L2 (0.36) | NFE2L2KIF11NPC1ALDH1A1MAPT | |
| SCHEMBL9837549 | 0.74 | ALDH1A1 (0.36) | NFE2L2KIF11NPC1ALDH1A1MAPT | |
| SCHEMBL9837883 | 0.73 | NFE2L2 (0.39) | NFE2L2KIF11NPC1ALDH1A1MAPT | |
| SCHEMBL9837533 | 0.73 | EPHX1 (0.38) | NFE2L2NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL9838727 | 0.72 | NFE2L2 (0.38) | NFE2L2LDLRNPC1RAB9AHSD11B1 | |
| SCHEMBL9837560 | 0.71 | NFE2L2 (0.40) | NFE2L2LDLRNPC1RAB9AHSD11B1 | |
| SCHEMBL14143516 | 0.70 | MAPT (0.50) | KIF11NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL20423878 | 0.69 | NFE2L2 (0.55) | NFE2L2KIF11LDLRMAOB | |
| SCHEMBL9837578 | 0.69 | NFE2L2 (0.47) | NFE2L2CYP19A1SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276122-B1 | CYCLOALKYL-SUBSTITUTED 4-AMINOPHENYL HALO DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-08-07 | — | — | EP | claimed |
| EP-0276122-A2 | Cycloalkyl-substituted 4-aminophenyl halo derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-07-27 | — | — | EP | claimed |
| EP-0276122-B1 | CYCLOALKYL-SUBSTITUTED 4-AMINOPHENYL HALO DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-08-07 | — | — | EP | disclosed |
| US-4847295-A | ANTITUMOR AGENTS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-07-11 | — | — | US | disclosed |
| EP-0276122-A2 | Cycloalkyl-substituted 4-aminophenyl halo derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-07-27 | — | — | EP | disclosed |