Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | LDLR | P01130 | 1/20 | 0.38 |
| ▸ | MLYCD | O95822 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.38 |
| ▸ | LIPA | P38571 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9838727 | 0.99 | NFE2L2 (0.38) | NFE2L2LDLRMLYCDHDAC6CSNK1D | |
| SCHEMBL9838824 | 0.81 | ALDH1A1 (0.48) | HSD11B1EPHX1POLBSMN1; SMN2 | |
| SCHEMBL9837515 | 0.80 | ALDH1A1 (0.46) | HSD11B1EPHX1POLBSMN1; SMN2GAA | |
| SCHEMBL9837608 | 0.74 | CYP19A1 (0.51) | HSD11B1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9837558 | 0.74 | RAB9A (0.51) | EPHX2RAB9AEPHX1SMN1; SMN2GAA | |
| SCHEMBL9837839 | 0.73 | NFE2L2 (0.47) | NFE2L2LDLRMLYCDHDAC6HSD11B1 | |
| SCHEMBL9838913 | 0.72 | RAB9A (0.49) | EPHX2RAB9AEPHX1SMN1; SMN2GAA | |
| SCHEMBL9837262 | 0.72 | CYP19A1 (0.49) | RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9838902 | 0.71 | NFE2L2 (0.45) | NFE2L2LDLRHSD11B1RAB9ANPC1 | |
| SCHEMBL9838945 | 0.70 | NFE2L2 (0.39) | NFE2L2MLYCDHDAC6AAK1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276122-B1 | CYCLOALKYL-SUBSTITUTED 4-AMINOPHENYL HALO DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-08-07 | — | — | EP | claimed |
| EP-0276122-A2 | Cycloalkyl-substituted 4-aminophenyl halo derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-07-27 | — | — | EP | claimed |
| EP-0276122-B1 | CYCLOALKYL-SUBSTITUTED 4-AMINOPHENYL HALO DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-08-07 | — | — | EP | disclosed |
| US-4847295-A | ANTITUMOR AGENTS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-07-11 | — | — | US | disclosed |
| EP-0276122-A2 | Cycloalkyl-substituted 4-aminophenyl halo derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-07-27 | — | — | EP | disclosed |