Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | LDLR | P01130 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | MLYCD | O95822 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9838902 | 0.98 | NFE2L2 (0.45) | NFE2L2LDLRKIF11CYP19A1HSD11B1 | |
| SCHEMBL9837533 | 0.75 | EPHX1 (0.38) | NFE2L2ALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL9837883 | 0.75 | NFE2L2 (0.39) | NFE2L2KIF11CYP19A1HSD11B1ALDH1A1 | |
| SCHEMBL9837549 | 0.73 | ALDH1A1 (0.36) | NFE2L2KIF11ALDH1A1NPC1MAPT | |
| SCHEMBL9837596 | 0.73 | NFE2L2 (0.36) | NFE2L2KIF11CYP19A1ALDH1A1NPC1 | |
| SCHEMBL9837560 | 0.73 | NFE2L2 (0.40) | NFE2L2LDLRHSD11B1MLYCDHDAC6 | |
| SCHEMBL9838727 | 0.71 | NFE2L2 (0.38) | NFE2L2LDLRHSD11B1MLYCDHDAC6 | |
| SCHEMBL20423878 | 0.71 | NFE2L2 (0.55) | NFE2L2LDLRKIF11 | |
| SCHEMBL18151840 | 0.70 | NFE2L2 (0.43) | NFE2L2LDLRKIF11CYP19A1HSD11B1 | |
| SCHEMBL9837901 | 0.70 | NFE2L2 (0.50) | NFE2L2LDLRCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276122-B1 | CYCLOALKYL-SUBSTITUTED 4-AMINOPHENYL HALO DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-08-07 | — | — | EP | claimed |
| EP-0276122-B1 | CYCLOALKYL-SUBSTITUTED 4-AMINOPHENYL HALO DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-08-07 | — | — | EP | disclosed |
| US-4847295-A | ANTITUMOR AGENTS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-07-11 | — | — | US | disclosed |
| EP-0276122-A2 | Cycloalkyl-substituted 4-aminophenyl halo derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-07-27 | — | — | EP | disclosed |