SCHEMBL98393

SCHEMBL98393

C[CH]NC(=O)Cc1ccc(CO)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.43
ALDH1A1 P00352 2/20 0.42
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
AOC2 O75106 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
HPGD P15428 3/20 0.41
GAA P10253 2/20 0.41
LMNA P02545 1/20 0.41
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
CNR2 P34972 1/20 0.40
HDAC8 Q9BY41 2/20 0.39
HDAC6 Q9UBN7 1/20 0.39
CYP4F2 P78329 1/20 0.39
CYP4A11 Q02928 1/20 0.39
HDAC2 Q92769 1/20 0.39
EGFR P00533 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4680710 0.84 MEN1 (0.59) ALDH1A1MEN1KMT2AL3MBTL1NPC1
SCHEMBL333393 0.79 LMNA (0.49) HTTALDH1A1MEN1KMT2AAOC2
SCHEMBL19579523 0.77 MEN1 (0.56) MEN1KMT2ARAB9AGAA
SCHEMBL31344791 0.76 HPGD (0.50) HTTALDH1A1MEN1KMT2AL3MBTL1
SCHEMBL743447 0.75 MEN1 (0.42) HTTALDH1A1MEN1KMT2AAOC2
SCHEMBL27099071 0.75 AOC2 (0.61) MEN1KMT2AAOC2HPGDCA1
SCHEMBL7929809 0.72 LMNA (0.44) HTTALDH1A1MEN1KMT2AL3MBTL1
SCHEMBL23723912 0.72 ALDH1A1 (0.43) ALDH1A1MEN1KMT2AL3MBTL1NPC1
SCHEMBL9149413 0.72 POLB (0.53) ALDH1A1KMT2AHPGDCA1CA2
SCHEMBL112297 0.71 CYP4F2 (0.71) HTTALDH1A1KMT2AL3MBTL1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 261 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024071320-A1 COMPOUND PRODUCTION METHOD 国立大学法人東京大学 2024-04-04 WO disclosed
US-20240066132-A1 NOVEL FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES NOVARTIS AG (CH) 2024-02-29 US disclosed
US-11752211-B2 Fatty acids and their use in conjugation to biomolecules NOVARTIS AG (CH) 2023-09-12 US disclosed
EP-3988170-A1 FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES Novartis AG (CH) 2022-04-27 EP disclosed
US-20220024981-A1 CYCLIC PEPTIDES AS PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) INHIBITORS FOR THE TREATMENT OF METABOLIC DISORDERS NOVARTIS AG (CH) 2022-01-27 US disclosed
EP-3157571-B1 FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES NOVARTIS AG (CH) 2021-11-24 EP disclosed
EP-3887388-A1 CYCLIC PEPTIDES AS PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) INHIBITORS FOR THE TREATMENT OF METABOLIC DISORDERS Novartis AG (CH) 2021-10-06 EP disclosed
EP-3851445-A1 SITE SPECIFIC PROTEIN MODIFICATIONS Novartis AG (CH) 2021-07-21 EP disclosed
US-20210138037-A1 NOVEL APPLICATION OF HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE GROWTH FACTOR FOR MEDICAL PURPOSES KAGOSHIMA UNIVERSITY (JP) 2021-05-13 US disclosed
US-10905742-B2 Application of heparin-binding epidermal growth factor-like growth factor for medical purposes KAGOSHIMA UNIVERSITY (JP) 2021-02-02 US disclosed
EP-0873998-A2 Receptor protein and its use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-10-28 EP disclosed
WO-1998046767-A1 PROTEINS HAVING LECITHIN-CHOLESTEROL ACYLTRANSFERASE-LIKE ACTIVITY, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-10-22 WO disclosed
EP-0870020-A2 LIGAND POLYPEPTIDES FOR THE G-PROTEIN-COUPLED RECEPTOR PROTEIN, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1998-10-14 EP disclosed
EP-0856582-A2 Inhibitor protein of transcription factors and its DNA Takeda Chemical Industries, Ltd. (JP) 1998-08-05 EP disclosed
WO-1998011130-A2 MAMMALIAN EPENDYMIN-LIKE PROTEINS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-03-19 WO disclosed
EP-0824149-A2 Glutamine: fructose-6-phosphate amidotransferase (GFAT), its production and use Takeda Chemical Industries, Ltd. (JP) 1998-02-18 EP disclosed
WO-1998003648-A1 FAS LIGAND-LIKE PROTEIN, ITS PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-01-29 WO disclosed
WO-1997040157-A1 MATRIX METALLOPROTEASE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-10-30 WO disclosed
EP-0799892-A2 Calpain, its production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-10-08 EP disclosed
WO-1997024436-A2 LIGAND POLYPEPTIDES FOR THE G-PROTEIN-COUPLED RECEPTOR PROTEIN, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-07-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240066132-A1 NOVEL FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES FABP1, FABP2, FABP3 HTT 2558/4885ALDH1A1 849/4885MEN1 1252/4885
US-11752211-B2 Fatty acids and their use in conjugation to biomolecules FABP1, FABP2, FABP3 HTT 2474/4885ALDH1A1 907/4885MEN1 1307/4885
US-20220024981-A1 CYCLIC PEPTIDES AS PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) INHIBITORS FOR THE TREATMENT OF METABOLIC DISORDERS PCSK9, PCSK7, PCSK6 HTT 1816/4885ALDH1A1 4857/4885MEN1 416/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.