Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A known ✓ | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B known ✓ | P49841 | 1/20 | 0.42 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29010798 | 0.92 | GSK3A (0.50) | GSK3AGSK3BCCR6MAPTKMT2A | |
| SCHEMBL29010973 | 0.92 | GSK3A (0.50) | GSK3AGSK3BCCR6MAPTKMT2A | |
| SCHEMBL4938638 | 0.92 | GSK3A (0.50) | GSK3AGSK3BCCR6MAPTKMT2A | |
| Methylcyclopentane SCHEMBL29010800 | 0.90 | GSK3A (0.52) | GSK3AGSK3BCCR6MAPTKMT2A | |
| SCHEMBL29010977 | 0.83 | GSK3A (0.55) | GSK3AGSK3BCCR6MAPTKMT2A | |
| SCHEMBL316039 | 0.79 | GSK3A (0.41) | GSK3AGSK3BCCR6KMT2AACHE | |
| SCHEMBL29010933 | 0.79 | GSK3A (0.61) | GSK3AGSK3BCCR6CRBN | |
| Bicarbonate SCHEMBL17847302 | 0.78 | EPHX1 (0.50) | MAPTKMT2AEPHX1CA1CA2 | |
| SCHEMBL20561062 | 0.78 | GSK3A (0.44) | GSK3AGSK3BCCR6KDM4EPOLB | |
| Bicarbonate SCHEMBL4695324 | 0.78 | EPHX1 (0.50) | MAPTKMT2AEPHX1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411907-A2 | Scattered total internal reflectance apparatus | ORTHO DIAGNOSTIC SYSTEMS INC. (US) | 1991-02-06 | — | — | EP | disclosed |