Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 3/20 | 0.40 |
| ▸ | MMP9 | P14780 | 3/20 | 0.40 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 2/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5447642 | 0.77 | MMP2 (0.44) | MMP2MMP9TDP1MMP13MMP14 | |
| SCHEMBL713351 | 0.76 | MMP9 (0.61) | MMP2MMP9AKR1B1MMP13LMNA | |
| SCHEMBL1861823 | 0.74 | MMP9 (0.59) | MMP2MMP9AKR1B1MMP13LMNA | |
| SCHEMBL3207324 | 0.74 | MMP9 (0.59) | MMP2MMP9AKR1B1MMP13LMNA | |
| SCHEMBL3660535 | 0.74 | CYP2C9 (0.64) | NPSR1AKR1A1AKR1B1TDP1KCNH2 | |
| SCHEMBL2615291 | 0.74 | MMP2 (0.65) | NPSR1METAP1MMP2MMP9TDP1 | |
| SCHEMBL542586 | 0.71 | LMNA (0.51) | MMP2MMP9AKR1A1AKR1B1MMP14 | |
| SCHEMBL17570773 | 0.71 | LMNA (0.51) | MMP2MMP9AKR1A1AKR1B1MMP14 | |
| SCHEMBL10929665 | 0.69 | CYP2C9 (0.79) | MMP2MMP9AKR1A1AKR1B1ADAM17 | |
| SCHEMBL20291007 | 0.67 | AKR1B1 (0.73) | MMP2MMP9AKR1A1AKR1B1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0137343-B1 | NOVEL OXOPYRIMIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Taro Pharmaceutical Industries Ltd. (IL) | 1991-12-04 | — | — | EP | disclosed |
| US-4628056-A | Novel oxopyrimidine derivatives, pharmaceutical compositions containing them and their use as anticonvulsant, antianxiety and muscle relaxant agents | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 1986-12-09 | — | — | US | disclosed |
| EP-0137343-A2 | Novel oxopyrimidine derivatives and pharmaceutical compositions containing them | Taro Pharmaceutical Industries Ltd. (IL) | 1985-04-17 | — | — | EP | disclosed |