SCHEMBL3207324

SCHEMBL3207324

O=C1NC(=O)C(c2ccccc2)(c2ccccc2)C(=O)N1.[KH]

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP9 P14780 5/20 0.59
MMP2 P08253 4/20 0.59
LMNA P02545 2/20 0.55
CYP2C9 P11712 3/20 0.54
KCNH2 Q12809 2/20 0.54
BLM P54132 2/20 0.54
PMP22 Q01453 2/20 0.54
CACNA1F O60840 1/20 0.54
ALDH1A1 P00352 1/20 0.54
MAPT P10636 1/20 0.54
HTR2A P28223 1/20 0.54
HRH1 P35367 1/20 0.54
SCN1A P35498 1/20 0.54
SCN4A P35499 1/20 0.54
CACNA1D Q01668 1/20 0.54
CACNA1S Q13698 1/20 0.54
CACNA1C Q13936 1/20 0.54
SCN5A Q14524 1/20 0.54
SCN2A Q99250 1/20 0.54
SCN3A Q9NY46 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL713351 0.98 MMP9 (0.61) MMP9MMP2LMNACYP2C9KCNH2
SCHEMBL3195931 0.95 MMP9 (0.59) MMP9MMP2LMNACYP2C9KCNH2
SCHEMBL1861823 0.95 MMP9 (0.59) MMP9MMP2LMNACYP2C9KCNH2
SCHEMBL30457291 0.79 LMNA (0.53) MMP9MMP2LMNACYP2C9KCNH2
SCHEMBL77738 0.74 MMP2 (1.00) MMP9MMP2CYP2C9KCNH2BLM
SCHEMBL7340621 0.74 MMP9 (0.57) MMP9MMP2LMNACYP2C9KCNH2
SCHEMBL5447642 0.74 MMP2 (0.44) MMP9MMP2LMNAKCNH2ALDH1A1
SCHEMBL4038795 0.74 MMP9 (0.57) MMP9MMP2LMNACYP2C9KCNH2
SCHEMBL9841218 0.74 NPSR1 (0.43) MMP9MMP2LMNAKCNH2AKR1B1
SCHEMBL11042592 0.74 MMP9 (0.57) MMP9MMP2LMNACYP2C9KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8076346-B2 Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid Taro Pharamaceutical Industries Ltd. (IL) 2011-12-13 US claimed
US-20100144769-A1 COMPOSITION AND METHOD FOR IMPROVED BIOAVAILABILITY AND ENHANCED BRAIN DELIVERY OF 5 5-DIPHENYL BARBITURIC ACID TARO PHARMACEUTICAL INDUSTRIES LIMITED (IL) 2010-06-10 US claimed
EP-1781294-A4 COMPOSITION AND METHOD FOR IMPROVED BIOAVAILABILITY AND ENHANCED BRAIN DELIVERY OF 5,5-DIPHENYL BARBITURIC ACID TARO PHARMA IND (IL) 2007-12-26 EP claimed
EP-1781294-A2 COMPOSITION AND METHOD FOR IMPROVED BIOAVAILABILITY AND ENHANCED BRAIN DELIVERY OF 5,5-DIPHENYL BARBITURIC ACID TARO PHARMACEUTICAL INDUSTRIES LIMITED (IL) 2007-05-09 EP claimed
US-20060122208-A1 Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) 2006-06-08 US claimed
WO-2006026095-A2 COMPOSITION AND METHOD FOR IMPROVED BIOAVAILABILITY AND ENHANCED BRAIN DELIVERY OF 5,5-DIPHENYL BARBITURIC ACID TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) 2006-03-09 WO claimed
EP-1625848-A1 Composition and method for enhanced delivery of 5,5-diphenyl barbituric acid Taro Pharmaceuticals North America, Inc. (KY) 2006-02-15 EP claimed
US-8076346-B2 Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid Taro Pharamaceutical Industries Ltd. (IL) 2011-12-13 US disclosed
US-20100144769-A1 COMPOSITION AND METHOD FOR IMPROVED BIOAVAILABILITY AND ENHANCED BRAIN DELIVERY OF 5 5-DIPHENYL BARBITURIC ACID TARO PHARMACEUTICAL INDUSTRIES LIMITED (IL) 2010-06-10 US disclosed
US-7683071-B2 Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid TARO PHARMACEUTICALS INDUSTRIES LTD. (IL) 2010-03-23 US disclosed
EP-2081576-A2 METHOD OF IMPROVING BIOAVAILABILITY FOR NON-SEDATING BARBITURATES Taro Pharmaceuticals North America, Inc. (KY) 2009-07-29 EP disclosed
WO-2008066704-A2 METHOD OF IMPROVING BIOAVAILABILITY FOR NON-SEDATING BARBITURATES TARO PHARMACEUTICALS NORTH AMERICA, INC. (KY) 2008-06-05 WO disclosed
US-20080132529-A1 Method of improving bioavailability for non-sedating barbiturates TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) 2008-06-05 US disclosed
EP-1781294-A4 COMPOSITION AND METHOD FOR IMPROVED BIOAVAILABILITY AND ENHANCED BRAIN DELIVERY OF 5,5-DIPHENYL BARBITURIC ACID TARO PHARMA IND (IL) 2007-12-26 EP disclosed
EP-1781294-A2 COMPOSITION AND METHOD FOR IMPROVED BIOAVAILABILITY AND ENHANCED BRAIN DELIVERY OF 5,5-DIPHENYL BARBITURIC ACID TARO PHARMACEUTICAL INDUSTRIES LIMITED (IL) 2007-05-09 EP disclosed
US-20060122208-A1 Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) 2006-06-08 US disclosed
WO-2006026095-A2 COMPOSITION AND METHOD FOR IMPROVED BIOAVAILABILITY AND ENHANCED BRAIN DELIVERY OF 5,5-DIPHENYL BARBITURIC ACID TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) 2006-03-09 WO disclosed
EP-1625848-A1 Composition and method for enhanced delivery of 5,5-diphenyl barbituric acid Taro Pharmaceuticals North America, Inc. (KY) 2006-02-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100144769-A1 COMPOSITION AND METHOD FOR IMPROVED BIOAVAILABILITY AND ENHANCED BRAIN DELIVERY OF 5 5-DIPHENYL BARBITURIC ACID CYP3A5, CA5A, FABP7 MMP9 2102/4885MMP2 2720/4885LMNA 2966/4885
US-20080132529-A1 Method of improving bioavailability for non-sedating barbiturates MTNR1B, GABRB3, GABBR1 MMP9 1648/4885MMP2 3057/4885LMNA 1968/4885
US-20060122208-A1 Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid CYP3A5, SLC1A5, HTR5A MMP9 2205/4885MMP2 2893/4885LMNA 3122/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.