SCHEMBL9841223

SCHEMBL9841223

CN1C(=O)N(C)C(=O)C(c2ccccc2)(c2ccccc2)C1=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 5/20 0.46
BACE2 Q9Y5Z0 4/20 0.46
REN P00797 1/20 0.46
APP P05067 1/20 0.46
TSHR P16473 1/20 0.44
CYP2C19 P33261 1/20 0.44
PKM P14618 1/20 0.44
ALDH1A1 P00352 4/20 0.43
LMNA P02545 4/20 0.43
MAPT P10636 1/20 0.43
MAPK1 P28482 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
HSD17B10 Q99714 1/20 0.43
KDM4C Q9H3R0 1/20 0.43
L3MBTL1 Q9Y468 2/20 0.40
CTSD P07339 1/20 0.39
HTR1A P08908 2/20 0.38
HTR7 P34969 2/20 0.38
HTR6 P50406 2/20 0.38
GRIN1 Q05586 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28127783 0.84 BACE1 (0.38) BACE1BACE2RENAPPTSHR
SCHEMBL16865397 0.79 BACE1 (0.43) BACE1BACE2RENAPPTSHR
SCHEMBL17794053 0.76 LMNA (0.68) BACE1BACE2RENAPPTSHR
SCHEMBL16867619 0.76 BACE1 (0.41) BACE1BACE2RENAPPTSHR
SCHEMBL17830174 0.75 HTR1A (0.46) BACE1BACE2RENAPPTSHR
SCHEMBL16865414 0.75 MAPT (0.53) BACE1BACE2RENAPPTSHR
SCHEMBL19923740 0.74 HTR1A (0.46) BACE1BACE2RENAPPTSHR
SCHEMBL16865431 0.72 CYP2C19 (0.41) BACE1BACE2RENAPPTSHR
SCHEMBL19923559 0.72 HTR1A (0.42) BACE1BACE2RENAPPTSHR
SCHEMBL10645739 0.71 ELANE (0.56) BACE1TSHRCYP2C19ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11031630-B2 Electrolyte and electrochemical device NINGDE AMPEREX TECHNOLOGY LIMITED (CN) 2021-06-08 US disclosed
US-20200243906-A1 ELECTROLYTE AND ELECTROCHEMICAL DEVICE NINGDE AMPEREX TECHNOLOGY LIMITED 2020-07-30 US disclosed
EP-0137343-B1 NOVEL OXOPYRIMIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Taro Pharmaceutical Industries Ltd. (IL) 1991-12-04 EP disclosed
US-4628056-A Novel oxopyrimidine derivatives, pharmaceutical compositions containing them and their use as anticonvulsant, antianxiety and muscle relaxant agents TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) 1986-12-09 US disclosed
EP-0137343-A2 Novel oxopyrimidine derivatives and pharmaceutical compositions containing them Taro Pharmaceutical Industries Ltd. (IL) 1985-04-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200243906-A1 ELECTROLYTE AND ELECTROCHEMICAL DEVICE CACNA1B, NCS1, CA3 BACE1 4026/4885BACE2 4399/4885REN 2832/4885
US-11031630-B2 Electrolyte and electrochemical device CACNA1B, NCS1, CA3 BACE1 4026/4885BACE2 4399/4885REN 2832/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.