Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.49 |
| ▸ | TOP1 | P11387 | 2/20 | 0.46 |
| ▸ | TOP2A | P11388 | 1/20 | 0.46 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.46 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | TERT | O14746 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL892704 | 0.79 | HTT (0.54) | NPC1RAB9AMEN1KMT2AHTT | |
| SCHEMBL6029925 | 0.77 | NPC1 (0.82) | NPC1RAB9AMEN1KMT2ATP53 | |
| SCHEMBL4946074 | 0.76 | NPC1 (0.73) | NPC1RAB9AMEN1KMT2ATP53 | |
| SCHEMBL1470784 | 0.76 | NPC1 (0.73) | NPC1RAB9AMEN1KMT2ATP53 | |
| SCHEMBL9842945 | 0.74 | HSD17B2 (0.38) | NPC1RAB9AMEN1KMT2ATP53 | |
| SCHEMBL9842954 | 0.74 | NQO2 (0.54) | NPC1RAB9AMEN1KMT2ATP53 | |
| SCHEMBL18086516 | 0.73 | RAB9A (0.68) | NPC1RAB9AMEN1KMT2ATP53 | |
| SCHEMBL9081513 | 0.73 | TRPV1 (0.50) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL1520536 | 0.73 | HDAC1 (0.70) | TP53GAALMNAHTTHDAC1 | |
| SCHEMBL462324 | 0.73 | MEN1 (0.66) | NPC1RAB9AMEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0440503-A1 | 4-Isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-08-07 | — | — | EP | disclosed |