Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RPS6KA2 | Q15349 | 4/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9259274 | 0.87 | KDM4E (0.39) | SRD5A1SMN1; SMN2HSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL9261555 | 0.80 | HTR2A (0.49) | SRD5A1SMN1; SMN2RPS6KA2HSD17B10ALDH1A1 | |
| SCHEMBL9259549 | 0.77 | HTR2A (0.44) | RPS6KA3L3MBTL1NOTUM | |
| SCHEMBL9735949 | 0.70 | HTR2A (0.45) | SRD5A1HSD17B10ALDH1A1MAPTKDM4E | |
| SCHEMBL9264795 | 0.70 | KDM4E (0.56) | SRD5A1SMN1; SMN2HSD17B10ALDH1A1L3MBTL1 | |
| SCHEMBL9736283 | 0.70 | SRD5A1 (0.40) | SRD5A1SMN1; SMN2HSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL3083411 | 0.69 | RPS6KA3 (0.52) | RPS6KA2RPS6KA3ALDH1A1CYP1A2 | |
| SCHEMBL9279188 | 0.69 | ALOX5 (0.37) | HSD17B10ALDH1A1CYP1A2CYP2A6MAPT | |
| SCHEMBL9387355 | 0.68 | HTR2A (0.41) | RPS6KA2RPS6KA3HSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL13618587 | 0.68 | PABPC1 (0.49) | SMN1; SMN2HSD17B10ALDH1A1CYP1A2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | disclosed |