Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | SMARCA4 | P51532 | 6/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 3/20 | 0.41 |
| ▸ | PDE5A | O76074 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | TERT | O14746 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10725922 | 0.90 | KDM4E (0.54) | KDM4ERECQLMAPTPABPC1HTR2A | |
| SCHEMBL18202181 | 0.79 | PABPC1 (0.49) | KDM4ERECQLMAPTPABPC1SMARCA4 | |
| SCHEMBL18202213 | 0.79 | PABPC1 (0.49) | KDM4ERECQLMAPTPABPC1HTR2A | |
| SCHEMBL19960975 | 0.79 | PABPC1 (0.45) | KDM4ERECQLMAPTPABPC1HTR2A | |
| SCHEMBL9735614 | 0.77 | ACHE (0.41) | KDM4ERECQLMAPTPABPC1TP53 | |
| SCHEMBL15349503 | 0.77 | PARP1 (0.56) | KDM4ERECQLMAPTHTR2AHTR2C | |
| SCHEMBL9736655 | 0.75 | KDM4E (0.37) | KDM4ERECQLMAPTPABPC1TP53 | |
| SCHEMBL10726825 | 0.74 | KDM4E (0.48) | KDM4ERECQLMAPTHTR2AHTR2C | |
| SCHEMBL18202172 | 0.73 | HTR2A (0.55) | KDM4ERECQLMAPTHTR2AHTR2C | |
| SCHEMBL11009068 | 0.73 | KDM4E (0.47) | KDM4ERECQLMAPTHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | disclosed |
| US-4778812-A | ANTIHYPOXIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-10-18 | — | — | US | disclosed |