Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | USP14 | P54578 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9736347 | 0.72 | GALR3 (0.41) | ACHEKDM4EPOLBHPGDALDH1A1 | |
| SCHEMBL10725922 | 0.69 | KDM4E (0.54) | ACHEKDM4EMAPTRECQLL3MBTL1 | |
| SCHEMBL9738037 | 0.68 | NPC1 (0.36) | NPC1RAB9AUSP14HIF1AHPGD | |
| SCHEMBL10725844 | 0.66 | HSD17B10 (0.52) | KDM4EMAPTRECQLALDH1A1CYP1A1 | |
| SCHEMBL6151617 | 0.64 | L3MBTL1 (0.58) | KDM4EMAPTNPC1POLBRAB9A | |
| SCHEMBL10729922 | 0.64 | GRIK2 (0.43) | KDM4EGRIK2HIF1AHPGDALDH1A1 | |
| SCHEMBL18202213 | 0.62 | PABPC1 (0.49) | ACHEKDM4EMAPTRECQLL3MBTL1 | |
| SCHEMBL2018382 | 0.62 | ALDH1A1 (0.41) | KDM4EMAPTNPC1RAB9AL3MBTL1 | |
| SCHEMBL24156364 | 0.61 | CRBN (0.62) | — | |
| SCHEMBL4454151 | 0.61 | LTA4H (0.55) | MAPTL3MBTL1HPGDALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992021678-A1 | LIPOXYGENASE INHIBITING PYRROLO [1,2a]INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-12-10 | — | — | WO | disclosed |