Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Formaldehyde. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formaldehyde SCHEMBL11317948 | 0.91 | TSHR (0.40) | KEAP1 | |
| Formaldehyde SCHEMBL11327926 | 0.84 | ALDH1A1 (0.33) | MAPT | |
| SCHEMBL28333387 | 0.68 | NFKB1 (0.37) | NFKB1NFKB2RELA | |
| SCHEMBL27405844 | 0.67 | NFKB1 (0.34) | MAPTNFKB1NFKB2RELA | |
| SCHEMBL31514269 | 0.64 | NFKB1 (0.38) | NFKB1NFKB2RELA | |
| SCHEMBL27633331 | 0.64 | NFKB1 (0.38) | NFKB1NFKB2RELA | |
| SCHEMBL27405297 | 0.64 | NFKB1 (0.38) | NFKB1NFKB2RELA | |
| SCHEMBL28833044 | 0.64 | NFKB1 (0.34) | NFKB1NFKB2RELA | |
| SCHEMBL28392491 | 0.64 | NFKB1 (0.35) | NFKB1NFKB2RELA | |
| Water SCHEMBL28875414 | 0.63 | NFKB1 (0.37) | NFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415422-A2 | Method for forming images | FUJI PHOTO FILM CO., LTD. (JP) | 1991-03-06 | — | — | EP | disclosed |