Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 3/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1997372 | 0.87 | CLK4 (0.49) | MMP12MMP13CLK4XDHSLC22A12 | |
| SCHEMBL15245751 | 0.84 | LOXL2 (0.59) | MMP12MMP13HDAC8CLK4PTPN5 | |
| SCHEMBL27787243 | 0.82 | CLK4 (0.63) | CLK4PTPN5XDHSLC22A12PGR | |
| SCHEMBL7660410 | 0.82 | MMP12 (0.55) | MMP12MMP13HDAC8CLK4PTPN5 | |
| SCHEMBL8982347 | 0.82 | CYP2A6 (0.57) | MMP12MMP13HDAC8CLK4PTPN5 | |
| SCHEMBL10244532 | 0.82 | CYP2A6 (0.57) | MMP12MMP13HDAC8CLK4PTPN5 | |
| SCHEMBL1998639 | 0.82 | MMP3 (0.47) | MMP12MMP13GABRG2GABRB3GABRA5 | |
| SCHEMBL19608719 | 0.81 | TSHR (0.58) | MMP12MMP13HDAC8CLK4PTPN5 | |
| SCHEMBL21189130 | 0.81 | CLK4 (0.57) | CLK4PTPN5XDHSLC22A12CHEK1 | |
| SCHEMBL1078454 | 0.81 | LOXL2 (0.52) | MMP12MMP13HDAC8GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0424317-A2 | Pyrimidines | CIBA-GEIGY AG (CH) | 1991-04-24 | — | — | EP | disclosed |