Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846203 | 0.86 | PDE3B (0.38) | PDE3BPDE3AMAPTKDM4EAPAF1 | |
| SCHEMBL9846298 | 0.84 | PDE3B (0.38) | PDE3BPDE3AMAPTKDM4EAPAF1 | |
| SCHEMBL27337641 | 0.80 | POLB (0.49) | PDE3BPDE3AMAPTKDM4EGAA | |
| SCHEMBL9278136 | 0.80 | MAPT (0.51) | PDE3BPDE3AMAPTKDM4EMAPK1 | |
| SCHEMBL9846183 | 0.79 | RXFP1 (0.38) | PDE3BPDE3AMAPTKDM4EAPAF1 | |
| SCHEMBL9164330 | 0.79 | MAPT (0.41) | PDE3BPDE3AMAPTKDM4EAPAF1 | |
| SCHEMBL9170296 | 0.78 | KDM4E (0.44) | PDE3BPDE3AMAPTKDM4EAPAF1 | |
| SCHEMBL9846107 | 0.78 | PDE3B (0.41) | PDE3BPDE3AMAPTKDM4EAPAF1 | |
| SCHEMBL9846383 | 0.77 | PDE3B (0.43) | PDE3BPDE3AMAPTKDM4EAPAF1 | |
| SCHEMBL9283645 | 0.77 | MAPT (0.48) | PDE3BPDE3AMAPTKDM4EAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |