Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGFRL1 | Q5TC84 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CPT1A | P50416 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.33 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301733 | 0.80 | CYP11B2 (0.40) | CYP11B2SMN1; SMN2CYP11B1CPT1AJAK2 | |
| SCHEMBL9303690 | 0.74 | OPRM1 (0.37) | OGFRL1OPRM1OPRK1OPRD1CPT1A | |
| SCHEMBL9301930 | 0.67 | HTT (0.45) | KMT2ACYP11B2SMN1; SMN2CYP11B1HPGD | |
| SCHEMBL2935668 | 0.64 | SMN1; SMN2 (0.42) | KMT2ASMN1; SMN2 | |
| SCHEMBL9301581 | 0.63 | HTT (0.50) | OGFRL1KMT2ACYP11B2SMN1; SMN2OPRM1 | |
| SCHEMBL8140544 | 0.63 | CCR1 (0.47) | KMT2ASMN1; SMN2 | |
| SCHEMBL7548869 | 0.63 | CCR1 (0.47) | KMT2ASMN1; SMN2 | |
| SCHEMBL16759937 | 0.62 | NOTUM (0.52) | OGFRL1KMT2ASMN1; SMN2 | |
| SCHEMBL2034147 | 0.60 | SMN1; SMN2 (0.46) | OGFRL1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL21660807 | 0.59 | HTT (0.43) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0433648-A1 | Substituted pyrimidobenzimidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1991-06-26 | — | — | EP | disclosed |