Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301581 | 0.87 | HTT (0.50) | HTTCYP11B1CYP11B2ALDH1A1KDM4E | |
| SCHEMBL9302311 | 0.87 | CYP11B2 (0.44) | HTTCYP11B1CYP11B2ALDH1A1KDM4E | |
| SCHEMBL9302130 | 0.86 | HTT (0.47) | HTTALDH1A1KDM4EMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9302957 | 0.86 | CYP11B1 (0.43) | HTTCYP11B1CYP11B2ALDH1A1KDM4E | |
| Acetic Acid SCHEMBL9301936 | 0.85 | CYP11B2 (0.44) | HTTCYP11B1CYP11B2ALDH1A1KDM4E | |
| SCHEMBL9303841 | 0.80 | HPGD (0.35) | HTTCYP11B1CYP11B2GPR174HPGD | |
| SCHEMBL9302144 | 0.79 | GRM5 (0.39) | CYP11B1CYP11B2ALDH1A1KDM4EMEN1 | |
| SCHEMBL9847732 | 0.76 | HTT (0.43) | HTTCYP11B1CYP11B2ALDH1A1KDM4E | |
| SCHEMBL9301733 | 0.76 | CYP11B2 (0.40) | HTTCYP11B1CYP11B2ALDH1A1KDM4E | |
| SCHEMBL9301681 | 0.76 | HTT (0.42) | HTTCYP11B1CYP11B2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5283248-A | Bactericides, enzyme inhibitor of DNA-gyrase in bacteria | HOFFMANN-LA ROCHE INC. (US) | 1994-02-01 | — | — | US | disclosed |