Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.37 |
| ▸ | OGFRL1 | Q5TC84 | 3/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9847716 | 0.85 | HDAC1 (0.36) | OPRM1OPRD1OGFRL1OPRK1RORC | |
| SCHEMBL9301818 | 0.85 | ATR (0.35) | OPRM1OPRD1OGFRL1OPRK1RORC | |
| SCHEMBL9302252 | 0.85 | ACHE (0.42) | OPRM1OPRD1OGFRL1RORC | |
| SCHEMBL9302144 | 0.83 | GRM5 (0.39) | OPRM1OPRD1OGFRL1OPRK1CPT1A | |
| SCHEMBL9303841 | 0.82 | HPGD (0.35) | OPRM1OPRD1OGFRL1OPRK1RORC | |
| SCHEMBL9301969 | 0.81 | GRM5 (0.42) | OPRM1OPRD1OGFRL1OPRK1RORC | |
| SCHEMBL9847728 | 0.74 | OGFRL1 (0.38) | OPRM1OPRD1OGFRL1OPRK1ALK | |
| SCHEMBL9303648 | 0.72 | ACE (0.34) | OPRM1OPRD1OGFRL1OPRK1ADORA3 | |
| SCHEMBL9301682 | 0.71 | RORC (0.42) | OPRM1OPRD1OGFRL1RORC | |
| SCHEMBL9303809 | 0.71 | HTT (0.41) | OPRM1OPRD1OGFRL1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5283248-A | Bactericides, enzyme inhibitor of DNA-gyrase in bacteria | HOFFMANN-LA ROCHE INC. (US) | 1994-02-01 | — | — | US | disclosed |
| EP-0433648-A1 | Substituted pyrimidobenzimidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1991-06-26 | — | — | EP | disclosed |