Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301681 | 0.92 | HTT (0.42) | HTTRORCOPRM1OPRD1OGFRL1 | |
| SCHEMBL9301682 | 0.90 | RORC (0.42) | HTTRORCOPRM1OPRD1OGFRL1 | |
| SCHEMBL9301581 | 0.90 | HTT (0.50) | HTTRORCOPRM1OPRD1OGFRL1 | |
| SCHEMBL9301471 | 0.90 | RORC (0.41) | HTTRORCOPRM1OPRD1OGFRL1 | |
| SCHEMBL9303809 | 0.90 | HTT (0.41) | HTTRORCOPRM1OPRD1OGFRL1 | |
| SCHEMBL9302442 | 0.88 | RORC (0.41) | HTTRORCOPRM1OPRD1OGFRL1 | |
| SCHEMBL9301575 | 0.86 | RORC (0.39) | HTTRORCOPRM1OPRD1OGFRL1 | |
| SCHEMBL9302252 | 0.85 | ACHE (0.42) | RORCOPRM1OPRD1OGFRL1GPR119 | |
| SCHEMBL9301590 | 0.82 | MAPT (0.45) | HTTRORCSMN1; SMN2MAPTLMNA | |
| Acetic Acid SCHEMBL9302467 | 0.81 | MAPT (0.47) | RORCOPRM1OPRD1OGFRL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0433648-A1 | Substituted pyrimidobenzimidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1991-06-26 | — | — | EP | disclosed |