Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.52 |
| ▸ | CTSS | P25774 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | CTSG | P08311 | 1/20 | 0.45 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.45 |
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 3/20 | 0.45 |
| ▸ | PPARA | Q07869 | 3/20 | 0.45 |
| ▸ | PPARD | Q03181 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5418894 | 0.93 | CTSS (0.48) | CTSKCTSSNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21531695 | 0.89 | GPR139 (0.53) | CTSKCTSSNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15283622 | 0.88 | CTSK (0.55) | CTSKCTSSATMCTSLCTSB | |
| SCHEMBL5394821 | 0.86 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2GPR139EPHX2 | |
| SCHEMBL28289884 | 0.85 | CTSK (0.53) | CTSKCTSSATMCTSLCTSB | |
| SCHEMBL28288450 | 0.85 | CTSK (0.53) | CTSKCTSSATMCTSLCTSB | |
| SCHEMBL17497816 | 0.83 | CTSK (0.53) | CTSKCTSSATMPPARGPPARA | |
| SCHEMBL17497818 | 0.83 | CTSK (0.53) | CTSKCTSSATMPPARGPPARA | |
| SCHEMBL6382995 | 0.83 | PPARA (0.57) | CTSKCTSSPPARGPPARAPPARD | |
| SCHEMBL3866896 | 0.81 | PPARA (0.49) | CTSKCTSSATMPRSS1CTSG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459730-A2 | Anti-tumour compounds | ZENECA LIMITED (GB) | 1991-12-04 | — | — | EP | disclosed |