Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.32 |
| ▸ | F2 | P00734 | 2/20 | 0.32 |
| ▸ | ELANE | P08246 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.32 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.32 |
| ▸ | NEK10 | Q6ZWH5 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.31 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.31 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9849287 | 0.90 | PLAU (0.40) | PLAUL3MBTL1KDM4EPLATMEN1 | |
| SCHEMBL9849182 | 0.74 | CACNA2D1 (0.42) | PLAUKDM4EPLATELANE | |
| SCHEMBL7433788 | 0.73 | KDM4E (0.54) | L3MBTL1KDM4EMEN1KMT2ABRAF | |
| SCHEMBL6274459 | 0.71 | KDM4E (0.44) | L3MBTL1KDM4EMEN1KMT2ABRAF | |
| SCHEMBL7536284 | 0.71 | ESR1 (0.43) | MEN1KMT2AF2 | |
| SCHEMBL9849325 | 0.70 | PLAU (0.43) | PLAUL3MBTL1KDM4EPLATBRAF | |
| SCHEMBL27626910 | 0.69 | TTR (0.51) | L3MBTL1KDM4EMEN1KMT2ABRAF | |
| SCHEMBL9849262 | 0.69 | L3MBTL1 (0.39) | PLAUL3MBTL1KDM4EBRAFELANE | |
| Naphthalene SCHEMBL10758679 | 0.68 | CNR2 (0.51) | PLAUKDM4EMEN1KMT2ALCK | |
| SCHEMBL3168240 | 0.68 | ALDH1A1 (0.50) | L3MBTL1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421436-A2 | Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity | WARNER-LAMBERT COMPANY (US) | 1991-04-10 | — | — | EP | claimed |
| EP-0421436-A2 | Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity | WARNER-LAMBERT COMPANY (US) | 1991-04-10 | — | — | EP | disclosed |