Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9849332 | 0.89 | ALDH1A1 (0.33) | GAAKMT2AMEN1TSHR | |
| SCHEMBL21158809 | 0.86 | NAAA (0.34) | MGAMGAASIMGAM2KMT2A | |
| SCHEMBL2729288 | 0.77 | ALDH1A1 (0.38) | GAAKMT2AMEN1TSHR | |
| SCHEMBL1428501 | 0.76 | TSHR (0.48) | MGAMGAASIMGAM2KMT2A | |
| SCHEMBL15946658 | 0.71 | KMT2A (0.37) | KMT2AMEN1 | |
| SCHEMBL18471326 | 0.71 | CNR2 (0.41) | KMT2AMEN1TSHR | |
| SCHEMBL7263173 | 0.70 | MGAM (0.39) | MGAMGAASIMGAM2TSHR | |
| SCHEMBL103443 | 0.70 | — | — | |
| SCHEMBL103732 | 0.70 | — | — | |
| SCHEMBL21611684 | 0.70 | SLC15A1 (0.40) | MGAMGAASIMGAM2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421436-A2 | Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity | WARNER-LAMBERT COMPANY (US) | 1991-04-10 | — | — | EP | claimed |
| EP-0421436-A2 | Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity | WARNER-LAMBERT COMPANY (US) | 1991-04-10 | — | — | EP | disclosed |