Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.61 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.61 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 11/20 | 0.49 |
| ▸ | BRAF | P15056 | 11/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9850498 | 0.83 | BCHE (0.49) | JAK2JAK1TDO2 | |
| SCHEMBL9850466 | 0.83 | HTR1A (0.89) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL9850695 | 0.81 | HTR1A (0.58) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL9850424 | 0.81 | HTR1A (0.54) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL9850407 | 0.80 | HTR1A (0.73) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL9850549 | 0.80 | NOS1 (0.54) | JAK2JAK1TDO2 | |
| SCHEMBL9850419 | 0.78 | JAK2 (0.44) | RAF1BRAFJAK2JAK1TDO2 | |
| SCHEMBL10668370 | 0.77 | DRD2 (0.62) | JAK2JAK1TDO2 | |
| SCHEMBL9850606 | 0.77 | HTR1A (0.71) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL9850591 | 0.77 | HTR1A (0.71) | HTR1AADRA1DADRA1AADRA1BFERMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0443862-A1 | Triamine derivatives and their acid-addition salts | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1991-08-28 | — | — | EP | disclosed |