Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 5/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.56 |
| ▸ | BCHE | P06276 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | BACE1 | P56817 | 2/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9852247 | 0.93 | SIGMAR1 (0.59) | DRD4SIGMAR1TMEM97MAPK1 | |
| SCHEMBL9727255 | 0.86 | DRD4 (0.66) | DRD4SIGMAR1BCHEACHEBACE1 | |
| SCHEMBL9852220 | 0.81 | DRD4 (0.64) | DRD4SIGMAR1BCHEACHEBACE1 | |
| SCHEMBL9852237 | 0.76 | DRD4 (0.57) | DRD4SIGMAR1ACHE | |
| SCHEMBL9727243 | 0.76 | DRD4 (0.69) | DRD4SIGMAR1BCHEACHEBACE1 | |
| SCHEMBL9727177 | 0.76 | DRD4 (0.54) | DRD4SIGMAR1ACHE | |
| SCHEMBL9727088 | 0.75 | DRD4 (0.62) | DRD4SIGMAR1 | |
| SCHEMBL9727190 | 0.75 | DRD4 (0.62) | DRD4SIGMAR1 | |
| SCHEMBL20303658 | 0.74 | SIGMAR1 (0.76) | DRD4SIGMAR1BCHEACHEBACE1 | |
| SCHEMBL9481804 | 0.74 | MCHR1 (0.47) | DRD4SIGMAR1RAB9APRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416581-A1 | Substituted N-benzylpiperidine amides | G.D. Searle & Co. (US) | 1991-03-13 | — | — | EP | claimed |