Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.44 |
| ▸ | SI | P14410 | 1/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20954435 | 0.91 | MTNR1A (0.47) | MTNR1AMTNR1BMAPK1KDM4EHIF1A | |
| SCHEMBL11923029 | 0.86 | MTNR1A (0.47) | MTNR1AMTNR1BMAPK1KDM4EHIF1A | |
| SCHEMBL8054587 | 0.85 | MTNR1A (0.46) | MTNR1AMTNR1BMAPK1KDM4EHIF1A | |
| SCHEMBL279485 | 0.83 | MAPK1 (0.50) | MTNR1AMTNR1BMAPK1KDM4EHIF1A | |
| SCHEMBL5511272 | 0.81 | MTNR1A (0.43) | MTNR1AMTNR1BMAPK1KDM4EHIF1A | |
| SCHEMBL685408 | 0.80 | THRB (0.52) | MTNR1AMTNR1BMAPK1KDM4EHIF1A | |
| SCHEMBL14389742 | 0.80 | MTNR1A (0.44) | MTNR1AMTNR1BMAPK1KDM4EHIF1A | |
| SCHEMBL15604382 | 0.80 | MTNR1A (0.42) | MTNR1AMTNR1BMAPK1KDM4EHIF1A | |
| SCHEMBL10580277 | 0.79 | MAPK1 (0.46) | MTNR1AMTNR1BMAPK1KDM4EHIF1A | |
| SCHEMBL16677194 | 0.79 | MAPK1 (0.46) | MTNR1AMTNR1BMAPK1KDM4EHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101253164-B | Indole-3-carbonyl-spiro-piperidine derivatives as V1a receptor antagonists | HOFFMANN LA ROCHE | 2012-05-16 | — | — | CN | disclosed |
| EP-0413293-A2 | 1-(Benzo[b]thienyl)-2-(thienyl) ethenes and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-02-20 | — | — | EP | disclosed |
| US-4904674-A | FREE OF AGGLOMERATION OF FIBRILLATION | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-02-27 | — | — | US | disclosed |