Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.46 |
| ▸ | DRD1 known ✓ | P21728 | 3/20 | 0.44 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.44 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.44 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL167958 | 0.87 | DRD2 (0.59) | HTTCYP3A4MAPK1MEN1KMT2A | |
| Fumaric Acid SCHEMBL12467794 | 0.87 | DRD2 (0.59) | HTTCYP3A4MAPK1MEN1KMT2A | |
| SCHEMBL9615962 | 0.85 | SETD7 (0.59) | SETD7DRD2DRD1DRD5DRD3 | |
| Fumaric Acid SCHEMBL9517664 | 0.82 | HRH2 (0.53) | HTTCYP3A4MAPK1MEN1KMT2A | |
| Maleic Acid SCHEMBL9517655 | 0.82 | HRH2 (0.53) | HTTCYP3A4MAPK1MEN1KMT2A | |
| SCHEMBL11131856 | 0.78 | MAOA (0.68) | SETD7DRD2DRD1DRD5DRD3 | |
| SCHEMBL11141355 | 0.78 | DRD1 (0.54) | SETD7DRD2DRD1DRD5DRD3 | |
| Hydrochloric Acid SCHEMBL11095470 | 0.77 | MAOA (0.69) | MAPTSETD7DRD2DRD1DRD5 | |
| Hydrochloric Acid SCHEMBL11254459 | 0.77 | MAOA (0.53) | SETD7DRD2DRD1DRD5DRD3 | |
| Maleic Acid SCHEMBL7778373 | 0.75 | HCAR2 (0.50) | MEN1KMT2AHRH2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220290159-A1 | miRNAS FOR REDUCING VENTRICLE ENLARGEMENT | St. Jude Children's Research Hpspital, Inc. (US) | 2022-09-15 | — | — | US | disclosed |