Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F12 | P00748 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
| ▸ | NCF1 | P14598 | 1/20 | 0.52 |
| ▸ | NOS3 | P29474 | 1/20 | 0.52 |
| ▸ | NOS1 | P29475 | 1/20 | 0.52 |
| ▸ | NOS2 | P35228 | 1/20 | 0.52 |
| ▸ | BACE1 | P56817 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14361190 | 0.83 | LTA4H (0.57) | F12PLAUNCF1NOS3NOS1 | |
| SCHEMBL1884690 | 0.81 | TRPA1 (0.48) | MAPTNPC1RAB9AALDH1A1HPGD | |
| SCHEMBL1369945 | 0.79 | ALDH1A1 (0.45) | MAPTNPC1RAB9AALDH1A1HPGD | |
| SCHEMBL442767 | 0.79 | HTR1B (0.54) | MAPTRAB9AALDH1A1HPGDTDP1 | |
| SCHEMBL29577853 | 0.79 | HTR1B (0.54) | MAPTRAB9AALDH1A1HPGDTDP1 | |
| SCHEMBL6213751 | 0.78 | ALDH1A1 (0.50) | MAPTNPC1RAB9AALDH1A1HPGD | |
| SCHEMBL6080116 | 0.78 | LTA4H (0.58) | F12PLAUNCF1NOS3NOS1 | |
| SCHEMBL31061114 | 0.78 | LTA4H (0.58) | F12PLAUNCF1NOS3NOS1 | |
| Lithium SCHEMBL6571336 | 0.77 | HTR1B (0.52) | MAPTRAB9AALDH1A1HPGDTDP1 | |
| Methane SCHEMBL10959030 | 0.77 | HTR1B (0.52) | MAPTRAB9AALDH1A1HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0405426-A2 | Naphthylamino- and naphthyloxy-pyridinamines and related compounds, a process for their preparation and their use as dermatological agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-02 | — | — | EP | disclosed |