Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.45 |
| ▸ | ASPH | Q12797 | 1/20 | 0.45 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.36 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL811340 | 0.90 | DGAT1 (0.58) | DGAT1ROCK2KDM4EKEAP1NFE2L2 | |
| SCHEMBL6657490 | 0.88 | KEAP1 (0.46) | DGAT1ROCK2KDM4EKEAP1ASPH | |
| SCHEMBL1713733 | 0.87 | KDM4E (0.54) | DGAT1KDM4EKEAP1ASPHKDM8 | |
| SCHEMBL9853614 | 0.86 | KEAP1 (0.45) | DGAT1ROCK2KDM4EKEAP1ASPH | |
| SCHEMBL2323641 | 0.85 | DGAT1 (0.54) | DGAT1ROCK2KDM4EPARP1CES2 | |
| Ammonia Solution, Strong SCHEMBL10949233 | 0.84 | KEAP1 (0.44) | DGAT1ROCK2KDM4EKEAP1ASPH | |
| Hydrochloric Acid SCHEMBL29810612 | 0.83 | DGAT1 (0.52) | DGAT1ROCK2KDM4EKEAP1NFE2L2 | |
| SCHEMBL31258575 | 0.82 | KEAP1 (0.50) | KDM4EKEAP1ASPHKDM8NFE2L2 | |
| SCHEMBL363928 | 0.82 | KEAP1 (0.50) | KDM4EKEAP1ASPHKDM8NFE2L2 | |
| Hydrochloric Acid SCHEMBL11035410 | 0.80 | KEAP1 (0.48) | KDM4EKEAP1ASPHKDM8NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105538-B2 | 2-pyrrolidin-2-yl-[1,3,4]-oxadiazole compounds and their use as anti-depressants | GRUENENTHAL GMBH (DE) | 2006-09-12 | — | — | US | disclosed |
| US-20050187260-A1 | 2-Pyrrolidin-2-yl-[1,3,4]-oxadiazole compounds and their use as anti-depressants | GRUENENTHAL GMBH (DE) | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050187260-A1 | 2-Pyrrolidin-2-yl-[1,3,4]-oxadiazole compounds and their use as anti-depressants | OPRD1, OPRK1, GRIN2C | DGAT1 3267/4885ROCK2 1412/4885KDM4E 1219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.