Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.74 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.65 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9851543 | 0.94 | AGTR1 (0.66) | PPARGAGTR1AGTR2LMNAPDE4A | |
| SCHEMBL8566073 | 0.92 | PPARG (0.61) | PPARGAGTR1AGTR2LMNAPDE4A | |
| SCHEMBL9200503 | 0.85 | PPARG (1.00) | PPARGAGTR1AGTR2 | |
| SCHEMBL8874596 | 0.85 | PPARG (0.53) | PPARGAGTR1AGTR2LMNAENPP2 | |
| SCHEMBL8559933 | 0.84 | AGTR2 (0.66) | PPARGAGTR1AGTR2 | |
| SCHEMBL9854341 | 0.83 | PPARG (0.54) | PPARGAGTR1AGTR2LMNAPDE4A | |
| SCHEMBL9854386 | 0.83 | PPARG (0.53) | PPARGAGTR1AGTR2LMNAPDE4A | |
| SCHEMBL9854355 | 0.83 | PPARG (0.53) | PPARGAGTR1AGTR2LMNATP53 | |
| SCHEMBL9851425 | 0.82 | AGTR1 (0.56) | PPARGAGTR1AGTR2LMNAPDE4A | |
| SCHEMBL9854319 | 0.82 | BRD4 (0.53) | PPARGAGTR1AGTR2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0426021-A1 | Condensed imidazole derivatives and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-08 | — | — | EP | disclosed |
| EP-0415886-A2 | Aza compounds | CIBA-GEIGY AG (CH) | 1991-03-06 | — | — | EP | disclosed |