Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.44 |
| ▸ | CTSG | P08311 | 4/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 4/20 | 0.44 |
| ▸ | CMA1 | P23946 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14377773 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2CTRB1POLBGAARAB9A | |
| SCHEMBL5856865 | 0.73 | LMNA (0.53) | TDP1LMNAHSD17B10ALDH1A1RAB9A | |
| SCHEMBL7370159 | 0.73 | SMN1; SMN2 (0.63) | SMN1; SMN2TDP1PRSS1CTSGCTRB1 | |
| SCHEMBL8827819 | 0.73 | SMN1; SMN2 (0.63) | SMN1; SMN2PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL5857603 | 0.73 | CA2 (0.55) | TDP1LMNAHSD17B10 | |
| SCHEMBL8597091 | 0.72 | NAAA (0.57) | SMN1; SMN2LMNAPRSS1CTSGCTRB1 | |
| SCHEMBL1846885 | 0.72 | FFAR4 (0.44) | TDP1LMNAHSD17B10ALDH1A1 | |
| SCHEMBL9830868 | 0.72 | CA2 (0.53) | TDP1LMNAHSD17B10 | |
| SCHEMBL22223355 | 0.71 | FFAR4 (0.45) | TDP1LMNAHSD17B10ALDH1A1 | |
| SCHEMBL11012507 | 0.71 | PRSS1 (0.52) | TDP1LMNAHSD17B10PRSS1CTSG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0253179-B1 | A-ACYLAMINO AMINOALKYL PHOPHONATE ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E.R. Squibb & Sons, Inc. (US) | 1991-12-04 | — | — | EP | disclosed |
| EP-0253179-A2 | A-acylamino aminoalkyl phophonate angiotensin converting enzyme inhibitors | E.R. Squibb & Sons, Inc. (US) | 1988-01-20 | — | — | EP | disclosed |