Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.44 |
| ▸ | PPARA | Q07869 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9857098 | 0.83 | PDPK1 (0.55) | MAPTPDPK1ALDH1A1HSD17B10LMNA | |
| SCHEMBL578528 | 0.80 | ALDH1A1 (0.44) | MAPTPDPK1PPARAPOLBALDH1A1 | |
| SCHEMBL538763 | 0.74 | MAPT (0.52) | MAPTPPARAKMT2AMEN1NPC1 | |
| Methane SCHEMBL11382581 | 0.73 | MAPT (0.51) | MAPTPPARAKMT2AMEN1NPC1 | |
| SCHEMBL17766275 | 0.72 | MAPT (0.54) | MAPTKMT2AMEN1POLBKLK7 | |
| SCHEMBL10772140 | 0.72 | MAPT (0.42) | MAPTPPARAKMT2AMEN1POLB | |
| SCHEMBL4924113 | 0.71 | MAPT (0.47) | MAPTPPARAKMT2AMEN1NPC1 | |
| SCHEMBL7212425 | 0.71 | MMP8 (0.50) | PDPK1KMT2AMEN1NPC1 | |
| SCHEMBL9857925 | 0.70 | APAF1 (0.38) | MAPTPDPK1ALDH1A1HSD17B10LMNA | |
| SCHEMBL11713690 | 0.70 | MAPT (0.48) | MAPTPPARAKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5072023-A | Reacting lactone with ester anion to form cyclohexenone ester; oxidizing or dehydrogenating the intermediate | E. R. SQUIBB & SONS, INC. (US) | 1991-12-10 | — | — | US | disclosed |
| EP-0442495-A1 | Process for preparing highly substituted phenyls | E.R. SQUIBB & SONS, INC. (US) | 1991-08-21 | — | — | EP | disclosed |