Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TPMT | P51580 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 2/20 | 0.39 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1573045 | 0.85 | TPMT (0.56) | PPARAALDH1A1TPMTKDM4EGAA | |
| SCHEMBL3949729 | 0.81 | PPARA (0.46) | PPARAALDH1A1TPMTKDM4EGAA | |
| SCHEMBL985523 | 0.78 | ALDH1A1 (0.61) | ALDH1A1TPMTKDM4EGAATAS1R3 | |
| SCHEMBL4238364 | 0.78 | CA12 (0.50) | PPARAALDH1A1HTTKMT2ALMNA | |
| SCHEMBL1014238 | 0.77 | RORC (0.56) | RORCTAS1R3TAS1R1KMT2ALMNA | |
| SCHEMBL1814578 | 0.76 | KMT2A (0.47) | ALDH1A1GAAPLAUGLRA1HTT | |
| SCHEMBL1459275 | 0.75 | TPMT (0.50) | ALDH1A1TPMTPLAURORCHTT | |
| SCHEMBL19088279 | 0.74 | GAA (0.42) | ALDH1A1GAARORCHTTTP53 | |
| SCHEMBL31582335 | 0.74 | ABCB11 (0.41) | ALDH1A1TPMTKDM4EGAAPLAU | |
| SCHEMBL1013088 | 0.74 | RORC (0.42) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7875631-B2 | e.g.1-(3,5-dichlorophenyl)-2-formyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline; to prevent and/or treat cancer and other abnormal cell growth, and metabolic as well as blood vessel proliferate disorders, in which uncontrolled expression of insulin-like growth factor-1 receptor is observed | ANALYTECON S.A. (CH) | 2011-01-25 | — | — | US | disclosed |